PMID: 20104248DOI: 10.1038/ng0210-100Jan 28, 2010Paper
Deregulation of H3K27 methylation in cancer.
Nature Genetics
Eva Martinez-Garcia, Jonathan D Licht
Abstract
A new study now reports recurrent somatic mutation of EZH2, a histone methyltransferase that modifies H3K27, in diffuse large B-cell lymphoma (DLBCL). There is now evidence for both increased and decreased activity of enzymes controlling H3K27 methylation in cancer, suggesting that a precise balance of this methylation is critical for normal cell growth.
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