Deregulation of innate immune and inflammatory signaling in myelodysplastic syndromes

Leukemia
I Gañán-GómezGuillermo Garcia-Manero

Abstract

Myelodysplastic syndromes (MDSs) are a group of heterogeneous clonal hematologic malignancies that are characterized by defective bone marrow (BM) hematopoiesis and by the occurrence of intramedullary apoptosis. During the past decade, the identification of key genetic and epigenetic alterations in patients has improved our understanding of the pathophysiology of this disease. However, the specific molecular mechanisms leading to the pathogenesis of MDS have largely remained obscure. Recently, essential evidence supporting the direct role of innate immune abnormalities in MDS has been obtained, including the identification of multiple key regulators that are overexpressed or constitutively activated in BM hematopoietic stem and progenitor cells. Mounting experimental results indicate that the dysregulation of these molecules leads to abnormal hematopoiesis, unbalanced cell death and proliferation in patients' BM, and has an important role in the pathogenesis of MDS. Furthermore, there is compelling evidence that the deregulation of innate immune and inflammatory signaling also affects other cells from the immune system and the BM microenvironment, which establish aberrant associations with hematopoietic precursors and contribut...Continue Reading

References

Oct 1, 1992·The Journal of Experimental Medicine·R G HawleyT S Hawley
Apr 2, 1999·Science·M F PittengerD R Marshak
Jul 6, 2000·The EMBO Journal·A O AliprantisA Zychlinsky
Aug 3, 2002·Leukemia & Lymphoma·Amit Verma, Leonidas C Platanias
Sep 26, 2002·Cancer Causes & Control : CCC·Maria DalamagaDimitrios Trichopoulos
Sep 2, 2003·Nature Reviews. Immunology·Bharat B Aggarwal
Jan 7, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Liping YangSten Eirik W Jacobsen
Jul 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nadia FelliRuggero De Maria
Jan 18, 2006·Cell Death and Differentiation·N D Perkins, T D Gilmore
Jan 26, 2007·Nature Reviews. Cancer·Seth J CoreyAaron D Schimmer
Feb 24, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Christos I MaratheftisMichael Voulgarelis
Apr 7, 2007·Blood·Shahram Y KordastiGhulam J Mufti
Dec 1, 2007·Arthritis and Rheumatism·Olivier FainLoïc Guillevin

❮ Previous
Next ❯

Citations

Dec 25, 2015·Current Oncology Reports·Ali N ChamseddineGuillermo Garcia-Manero
Jun 18, 2016·International Journal of Molecular Sciences·Andreas GlenthøjKirsten Grønbæk
Aug 16, 2016·Clinical Lymphoma, Myeloma & Leukemia·Rami S Komrokji
Oct 14, 2016·Frontiers in Immunology·Darlene A MonlishLaura G Schuettpelz
Apr 4, 2017·American Journal of Hematology·May DaherGuillermo Garcia-Manero
Jun 16, 2017·Cytometry. Part B, Clinical Cytometry·Patricia FontJosé Luis Díez-Martín
May 10, 2017·Blood·Charlotte E M de MooijNicole M A Blijlevens
Feb 22, 2018·Proceedings of the National Academy of Sciences of the United States of America·Huiyuan ZhangStephanie S Watowich
Jun 21, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kohei HosokawaNeal S Young
Nov 29, 2017·Frontiers in Oncology·Shayda HemmatiKira Gritsman
Oct 20, 2017·Blood·James N Cooper, Neal S Young
May 19, 2018·The Journal of Experimental Medicine·Kelly MitchellUlrich Steidl
Jun 8, 2018·The Journal of Clinical Investigation·David J CorriganHans-Willem Snoeck
Aug 15, 2018·Blood·Laura BarreyroDaniel T Starczynowski
Jan 12, 2019·Current Opinion in Hematology·Namrata S ChandhokThomas Prebet
Mar 1, 2019·Leukemia·Alex BatallerGuillermo Garcia-Manero
May 24, 2018·Cardiovascular & Hematological Disorders Drug Targets·Ota Fuchs
May 24, 2019·JCI Insight·Shayda HemmatiKira Gritsman
Jul 10, 2019·Leukemia & Lymphoma·Justin D KanerAmit Verma
Jan 23, 2020·International Journal of Molecular Sciences·Christina K FerroneMichael J Rauh
Feb 18, 2020·Journal of Clinical Pharmacology·Afshin GhaderiAbbas Mirshafiey
Sep 1, 2017·Medical Oncology·Anacélia Gomes de MatosSilvia Maria Meira Magalhães
Dec 8, 2017·American Journal of Hematology·Guillermo Montalban-Bravo, Guillermo Garcia-Manero
Aug 10, 2019·International Journal of Molecular Sciences·Anne Sophie Kubasch, Uwe Platzbecker
Nov 15, 2019·HemaSphere·Katharina S Götze, Uwe Platzbecker
Nov 23, 2016·Frontiers in Immunology·Thomas ClapesEirini Trompouki

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Signaling & Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. This feed covers the latest research on signaling and epigenetics in cell growth and cancer.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

[Rinshō ketsueki] The Japanese journal of clinical hematology
Goro Sashida, Atsushi Iwama
Cellular and Molecular Life Sciences : CMLS
Lili YangSheng Wei
The Hematology Journal : the Official Journal of the European Haematology Association
Michel Delforge
© 2021 Meta ULC. All rights reserved