Deregulation of miR-183 and KIAA0101 in Aggressive and Malignant Pituitary Tumors

Frontiers in Medicine
Magali RocheJoël Lachuer

Abstract

Changes in microRNAs (miRNAs) expression in many types of cancer suggest that they may be involved in crucial steps during tumor progression. Indeed, miRNAs deregulation has been described in pituitary tumorigenesis, but few studies have described their role in pituitary tumor progression toward aggressiveness and malignancy. To assess the role of miRNAs within the hierarchical cascade of events in prolactin (PRL) tumors during progression, we used an integrative genomic approach to associate clinical-pathological features, global miRNA expression, and transcriptomic profiles of the same human tumors. We describe the specific down-regulation of one principal miRNA, miR-183, in the 8 aggressive (A, grade 2b) compared to the 18 non-aggressive (NA, grades 1a, 2a) PRL tumors. We demonstrate that it acts as an anti-proliferative gene by directly targeting KIAA0101, which is involved in cell cycle activation and inhibition of p53-p21-mediated cell cycle arrest. Moreover, we show that miR-183 and KIAA0101 expression significantly correlate with the main markers of pituitary tumors aggressiveness, Ki-67 and p53. These results confirm the activation of proliferation in aggressive and malignant PRL tumors compared to non-aggressive ones....Continue Reading

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Citations

Dec 18, 2016·Pituitary·Daniel A DonohoJohn D Carmichael
Mar 24, 2020·Endocrine Reviews·Vinaya Srirangam Nadhamuni, Márta Korbonits
Dec 28, 2019·Journal of Clinical Medicine·Christina Tatsi, Constantine A Stratakis
May 30, 2019·Frontiers in Endocrinology·Blake M HauserIan F Dunn
Oct 8, 2020·International Journal of Molecular Sciences·Ozal BeylerliGjumrakch Aliev
Sep 9, 2021·Nature Reviews. Endocrinology·Gérald RaverotThierry Brue
Apr 4, 2019·Neuroendocrinology·Jacqueline TrouillasGerald Raverot

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Datasets Mentioned

BETA
GSE46294

Methods Mentioned

BETA
feature extraction
PCR
Transfection
immunoprecipitation
Assay
FACS
ChIP
genotyping
transcriptomic

Software Mentioned

Agilent
Modfit LT
GeneSpring
Ingenuity Pathway Analysis
TargetScan
RQ Manager

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