Deregulation of p27 and cyclin D1/D3 control over mitosis is associated with unfavorable prognosis in non-small cell lung cancer, as determined in 405 operated patients

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer
William SterlacciAlexandar Tzankov

Abstract

A large group of interacting molecular factors, involved in epithelial-mesenchymal transition, epidermal growth factor receptor (EGFR) signaling, and G1 mitotic phase, are shown to play an important role in cancerogenesis and progression of non-small cell lung cancer (NSCLC). Since success concerning potential correlations, structural and numeric gene aberrations, and biological risk assessment of these molecular factors are still lacking, combined analysis of a multitude of intertwined factors is currently a promising approach. Cyclins (D1, D2, D3, and E), p21, p27, EGFR, Snail, E-cadherin, beta-catenin, phosphatidylinositol-3' kinase, phosphatase and tensin homologue, phosphorylated Akt, and phosphorylated signal transducer, and activator of transcription-3 were analyzed by immunohistochemistry in 405 surgically resected NSCLC, using a standardized tissue microarray platform. In addition, the gene status of EGFR and cyclin D1 was examined by fluorescence in situ hybridization. Extensive clinical data were acquired, enabling detailed clinicopathologic correlation during a postoperative follow-up period of up to 14 years. The protein overexpressions of nuclear p27, cyclin D1, cyclin D3, E-cadherin, and EGFR as assessed by immun...Continue Reading

References

Feb 14, 1998·International Journal of Cancer. Journal International Du Cancer·A MarchettiG Bevilacqua
Feb 23, 1999·The American Journal of Pathology·R V LloydB W Scheithauer
Jul 1, 1999·Genes & Development·C J Sherr, J M Roberts
Jun 13, 2000·Oncogene·T BowmanR Jove
Sep 4, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Fred R HirschWilbur A Franklin
Sep 23, 2003·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Mitsuya IshikawaShiro Nozawa
Dec 18, 2003·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G SelvaggiG V Scagliotti
Feb 18, 2004·Nature Reviews. Cancer·Hua Yu, Richard Jove
Mar 17, 2004·Cancer Treatment Reviews·Juan Angel Fresno VaraManuel González-Barón
Oct 27, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Odile DavidArnold R Brody
Mar 3, 2005·Journal of the National Cancer Institute·Hisayuki ShigematsuAdi F Gazdar
May 3, 2005·Nature Reviews. Cancer·Nancy E Hynes, Heidi A Lane
May 5, 2005·Journal of the National Cancer Institute·Federico CappuzzoMarileila Varella-Garcia
Jun 3, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sunil SinghalSteven M Albelda
Oct 31, 2006·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Oliver GautschiJim Heighway
Aug 3, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jeffrey A Engelman
Aug 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Mei-Yi LeeMeng-Ru Shen
Dec 6, 2008·Folia Histochemica Et Cytobiologica·Hong-Tao XuEn-Hua Wang

❮ Previous
Next ❯

Citations

May 31, 2013·Journal of Biomedical Research·Wenze SunJie Cui
Jan 1, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Shinogu TakashimaYoshihiro Minamiya
Feb 13, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Radha MunagalaRamesh C Gupta
Oct 16, 2015·Molecular Medicine Reports·Daisuke MasudaMasayuki Iwazaki
Dec 19, 2013·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Willam SterlacciAlexandar Tzankov
Aug 23, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·William SterlacciSpasenija Savic
May 15, 2013·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Andreas PircherWolfgang Hilbe
Jan 10, 2012·Experimental Gerontology·William SterlacciMichael Fiegl
Nov 22, 2011·Surgical Oncology Clinics of North America·Betty C Tong, David H Harpole
Mar 18, 2011·American Journal of Clinical Pathology·William SterlacciMichael Fiegl
Apr 10, 2015·Virchows Archiv : an International Journal of Pathology·Geoffrey PommeAlexandar Tzankov
Jan 7, 2014·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Anne-Claire ToffartElisabeth Brambilla
Sep 1, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Yi ZhuangDe-Ping Zhang
Mar 24, 2012·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·William SterlacciAlexandar Tzankov
May 7, 2019·Applied Immunohistochemistry & Molecular Morphology : AIMM·William SterlacciAlexandar Tzankov
Jun 15, 2019·Cancer Cell International·Bo WangZhaohui Yang
Apr 21, 2018·Indian Journal of Pathology & Microbiology·William SterlacciAlexandar Tzankov
Apr 3, 2012·The International Journal of Biological Markers·Ting AiLiping Song
May 18, 2020·Seminars in Cell & Developmental Biology·Eva QuandtJosep Clotet

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.