Deregulation of the cell polarity protein Lethal giant larvae 2 (Lgl2) correlates with gastric cancer progression.

Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
Kyung Han NamHye Seung Lee

Abstract

We investigated the roles of Lethal giant larvae 2 (Lgl2), an epithelial cell polarity protein, during gastric carcinogenesis and gastric cancer (GC) progression and evaluated the correlation of Lgl2 with epithelial-mesenchymal transition (EMT) markers. Lgl2 protein and mRNA expression were determined by immunohistochemistry and mRNA in situ hybridization in a large series of GC and preneoplastic lesions. Additionally, expression of 7 EMT markers was examined by immunohistochemistry. Loss of membrane Lgl2 staining in GC was observed in 347 of 409 GCs. Lgl2 loss was associated with diffuse histological type (P < 0.001), advanced stage (P = 0.021), and worse prognosis (P = 0.047). Furthermore, Lgl2 loss correlated with reduced E-cadherin expression (P < 0.01) and increased expression of vimentin (P < 0.01). Combined analysis of Lgl2 and the EMT markers, S100A4 and MMP2, improved predictions of patient outcomes. During gastric carcinogenesis, membrane expression of Lgl2 was progressively lost in 4 % of normal mucosa, 75 % of intestinal metaplasia, 58 % of gastric dysplasia, 69 % of intestinal type GC, and 96 % of diffuse type GC. Our results suggest that Lgl2 loss occurs at an early stage of gastric carcinogenesis and contributes ...Continue Reading

References

Feb 17, 1999·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·T SugaiC Itoh
Dec 14, 1999·The American Journal of Pathology·K F BeckerH Höfler
Nov 5, 2002·The American Journal of Pathology·Erika RosivatzKarl-Friedrich Becker
Apr 15, 2003·The Journal of Pathology·Hye Seung LeeWoo Ho Kim
Apr 23, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Francesco GrazianoStefano Cascinu
Sep 20, 2005·Oncogene·S KuphalA K Bosserhoff
Dec 6, 2005·Virchows Archiv : an International Journal of Pathology·Erika RosivatzMario Sarbia
Jan 24, 2007·Journal of Cellular Physiology·Paraskevi VogiatziAntonio Giordano
May 18, 2007·Nature Reviews. Cancer·Héctor PeinadoAmparo Cano
Aug 19, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Birgit HotzHubert G Hotz
Dec 14, 2007·Oncology Research·Tetsushi TsurugaYuji Taketani
Jan 18, 2008·Cancer Research·Simone SpadernaThomas Brabletz
Apr 5, 2008·Journal of Cell Science·Minhui Lee, Valeri Vasioukhin
Nov 26, 2008·Oncogene·P O HumbertH E Richardson
Nov 26, 2008·Oncogene·G Moreno-BuenoA Cano
Nov 26, 2008·Oncogene·S Etienne-Manneville
May 2, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Mikhail LisovskyGregory Y Lauwers
May 19, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Xuefeng LuZhengjun Chen
Dec 1, 2009·Cell·Jean Paul ThieryM Angela Nieto
Feb 25, 2010·Annals of Surgical Oncology·Stephen B Edge, Carolyn C Compton
Oct 14, 2010·Virchows Archiv : an International Journal of Pathology·Mikhail LisovskyGregory Y Lauwers
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman
May 28, 2011·Cell Death and Differentiation·C Royer, X Lu
Dec 16, 2011·Nature Reviews. Cancer·Fernando Martin-Belmonte, Mirna Perez-Moreno
Apr 3, 2012·Seminars in Cancer Biology·Saskia I J EllenbroekJohn G Collard

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Citations

Feb 27, 2016·Bioarchitecture·Sofia Moreira, Eurico Morais-de-Sá
May 21, 2015·Cancer Informatics·Wan-Hsin LinPanos Z Anastasiadis
May 16, 2019·Proceedings of the National Academy of Sciences of the United States of America·Lior AlmagorWilliam I Weis
Aug 6, 2020·Clinical and Experimental Pharmacology & Physiology·Yi MiaoPeijun Liu
May 7, 2019·Canadian Journal of Gastroenterology & Hepatology·Alexander DesukiCarl C Schimanski

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