PMID: 16634286Apr 26, 2006Paper

Dereplication of pentacyclic triterpenoids in plants by GC-EI/MS

Phytochemical Analysis : PCA
Jian-Qiao GuBarbara N Timmermann

Abstract

Three common plant-derived pentacyclic triterpenoids, oleanolic acid (1), betulinic acid (2) and ursolic acid (3), have been found to exhibit moderate anti-tubercular activity in a microplate alamar blue assay. In order to facilitate the discovery of novel anti-tubercular leads with diverse chemical structures, a new and rapid GC-EI/MS method was developed simultaneously and unambiguously to dereplicate 1-3 as their methyl esters with limits of detection of 25.6, 26.9 and 26.8 ng, respectively.

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Citations

Nov 17, 2011·Antonie van Leeuwenhoek·Xueting LiuLixin Zhang
Mar 19, 2013·Biochemical Pharmacology·Muthu K ShanmugamAnupam Bishayee
Jul 8, 2010·The Journal of Antibiotics·Xiangyang LiuLixin Zhang
Jun 11, 2009·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sebastian JägerArmin Scheffler
Mar 2, 2012·Phytochemistry·Jacob Pollier, Alain Goossens
Oct 24, 2008·Journal of Mass Spectrometry : JMS·B Rhourri-FrihM Lafosse
May 1, 2015·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Hui TanKuniyoshi Shimizu
Jul 5, 2016·Natural Product Reports·Matthew T Henke, Neil L Kelleher
Dec 1, 2006·Journal of Mass Spectrometry : JMS

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