Derivation and Validation of a Novel Severity Scoring System for Pneumonia at Intensive Care Unit Admission.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Thomas A CarmoKevan M Akrami

Abstract

Severity stratification scores developed in intensive care units (ICUs) are used in interventional studies to identify the most critically ill. Studies that evaluate accuracy of these scores in ICU patients admitted with pneumonia are lacking. This study aims to determine performance of severity scores as predictors of mortality in critically ill patients admitted with pneumonia. Prospective cohort study in a general ICU in Brazil. ICU severity scores (Simplified Acute Physiology Score 3 [SAPS 3] and Sepsis-Related Organ Failure Assessment [qSOFA]), prognostic scores of pneumonia (CURB-65 [confusion, urea, respiratory rate, blood pressure, age] and CRB-65 [confusion, respiratory rate, blood pressure, age]), and clinical and epidemiological variables in the first 6 hours of hospitalization were analyzed. Two hundred patients were included between 2015 and 2018, with a median age of 81 years (interquartile range, 67-90 years) and female predominance (52%), primarily admitted from the emergency department (65%) with community-acquired pneumonia (CAP, 80.5%). SAPS 3, CURB-65, CRB-65,and qSOFA all exhibited poor performance in predicting mortality. Multivariate regression identified variables independently associated with mortality ...Continue Reading

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Citations

Aug 10, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Luis Felipe ReyesGrant Waterer
May 31, 2021·European Journal of Internal Medicine·Hiroshi Ito

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