Derivation of a cardiopoietic population from human mesenchymal stem cells yields cardiac progeny

Nature Clinical Practice. Cardiovascular Medicine
Atta Behfar, Andre Terzic

Abstract

Stem cells have emerged as a next-generation therapy for cardiovascular disease. Initial clinical trials in patients with myocardial infarction document improved cardiac performance after administration of stem cells, translating their regenerative potential from the bench to the bedside. However, the promise of stem cell-based therapy has yet to be fully exploited, in part due to varying degrees of efficacy on follow-up. Contributing to the uncertain outcome is the variable cardiogenic potential of patient-derived stem cells. A strategy mimicking cardiogenic signaling was here formulated to transform mesenchymal stem cells, derived from human bone marrow, into cardiac progenitors. We identified a set of recombinant trophic factors capable of collectively inducing nuclear translocation of cardiac-specific transcription factors, engaging mesenchymal stem cells into cardiopoiesis, and ultimately securing a phenotype with functional excitation-contraction coupling. Maximizing the cardiogenic potential of human mesenchymal stem cells achieves a critical step in optimizing therapeutic translation.

References

Nov 26, 1999·Circulation·S Oparil
Apr 5, 2001·Nature·D OrlicP Anversa
Jan 24, 2002·Nature·J A Towbin, N E Bowles
Jan 24, 2002·Nature·Piero Anversa, Bernardo Nadal-Ginard
Jun 22, 2002·Nature·Yuehua JiangCatherine M Verfaillie
Oct 11, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Atta BehfarMichel Pucéat
Feb 26, 2003·Circulation Research·Carmen Perez-TerzicMichel Pucéat
Apr 8, 2003·Journal of the American College of Cardiology·Philippe MenaschéDenis Duboc
Apr 19, 2003·The EMBO Journal·Denice M HodgsonAndre Terzic
Aug 2, 2003·Genes & Development·Eric N Olson, Michael D Schneider
Sep 25, 2003·Cell·Antonio P BeltramiPiero Anversa
May 4, 2004·Trends in Cardiovascular Medicine·Ann Foley, Mark Mercola
Jul 10, 2004·Circulation Research·Mark F Pittenger, Bradley J Martin
Jul 28, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Denice M HodgsonAndre Terzic
Sep 11, 2004·Circulation Research·Francisco Fernández-AvilésAna Sánchez
Oct 19, 2004·Journal of the American College of Cardiology·Volker SchächingerAndreas M Zeiher
Feb 5, 2005·Circulation Research·Kai C Wollert, Helmut Drexler
Feb 11, 2005·Nature·Karl-Ludwig LaugwitzKenneth R Chien
Mar 15, 2005·The Journal of Clinical Investigation·Stefanie DimmelerMichael D Schneider
Jun 21, 2005·Annals of the New York Academy of Sciences·Atta BehfarAndre Terzic

❮ Previous
Next ❯

Citations

Jun 1, 2008·Journal of Cardiovascular Translational Research·Randolph S Faustino, Andre Terzic
Jun 1, 2008·Journal of Cardiovascular Translational Research·Jozef BartunekAndre Terzic
Jun 19, 2010·Journal of Cardiovascular Translational Research·Ana ArmiñánPilar Sepúlveda
Feb 7, 2007·The Journal of Experimental Medicine·Atta BehfarAndre Terzic
Jan 11, 2008·Genome Biology·Randolph S FaustinoAndre Terzic
Sep 1, 2007·Future Cardiology·Jozef Bartunek, Marc Vanderheyden
Apr 23, 2014·Human Gene Therapy·Marguerite V Evans-GaleaMartin B Delatycki
Jul 8, 2014·Journal of Molecular and Cellular Cardiology·Noemi PavoMariann Gyöngyösi
Mar 30, 2016·Trends in Cardiovascular Medicine·Andre Terzic, Atta Behfar
Aug 31, 2014·Advanced Drug Delivery Reviews·Conn L HastingsGarry P Duffy
Feb 5, 2013·Journal of Tissue Engineering and Regenerative Medicine·Yuahn-Sieh HuangKuo-Hsing Ma
Oct 7, 2008·Journal of Molecular and Cellular Cardiology·Atta BehfarAndre Terzic
Dec 19, 2006·Journal of Molecular and Cellular Cardiology·Atta Behfar, Andre Terzic
May 1, 2008·Clinical and Translational Science·Atta Behfar, Andre Terzic
Jun 2, 2012·Biotechnology Journal·Gerrit ErdmannMichael Boutros
Jan 5, 2011·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·D Adam YoungKaren L Christman
May 3, 2012·Annals of the New York Academy of Sciences·Clifford D L FolmesAndre Terzic
Aug 8, 2014·Journal of Biomedical Materials Research. Part a·Jean-Pierre KaramClaudia N Montero-Menei
May 28, 2015·Biomarkers in Medicine·Ruben Crespo-DiazAtta Behfar
Dec 21, 2013·Journal of the American College of Cardiology·Jozef BartunekAndre Terzic
Apr 16, 2013·Journal of the American College of Cardiology·Charles E MurryW Robb MacLellan
Feb 13, 2009·Clinical Pharmacology and Therapeutics·J BartunekA Terzic
Jan 1, 2008·Drug Discovery Today. Disease Models·Todd Evans
Feb 25, 2017·Stem Cells·Caressa ChenIoannis Karakikes
Jan 28, 2017·Journal of Cellular Biochemistry·Armita Mahdavi GorabiAmirhossein Sahebkar
Mar 7, 2014·Nature Reviews. Cardiology·Atta BehfarBernard J Gersh
Jul 8, 2017·Circulation·Thomas EschenhagenJoseph A Hill
Oct 16, 2012·Circulation Research·Lorenzo GalluzziGuido Kroemer
Oct 25, 2014·Circulation Research·Atta Behfar, Andre Terzic
Jan 19, 2007·Nature Clinical Practice. Cardiovascular Medicine·Carmen Perez-TerzicAndre Terzic
Feb 28, 2006·Nature Clinical Practice. Cardiovascular Medicine·Warren ShermanTomasz Siminiak
Mar 5, 2020·Stem Cells·Karen M PetersonMartin Rodriguez-Porcel
Jun 30, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Paolo FiorinaReza Abdi
Mar 21, 2020·Npj Regenerative Medicine·D Kent ArrellAndre Terzic

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Cardiac Regeneration

Cardiac regeneration enables the repair of irreversibly damaged heart tissue using cutting-edge science, including stem cell and cell-free therapy. Discover the latest research on cardiac regeneration here.