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Derivation of a JC virus-resistant human glial cell line: implications for the identification of host cell factors that determine viral tropism

Virology

Oct 1, 2003

Gretchen V GeeW J Atwood

PMID: 14517064

Abstract

JC virus (JCV) is a common human polyomavirus that infects 70-80% of the population worldwide. In immunosuppressed individuals, JCV infects oligodendrocytes and causes a fatal demyelinating disease known as progressive multifocal leukoencephalopathy (PML). The tropism of JCV is restrict...read more

Mentioned in this Paper

Transfection
Latent Virus Infection Process
Leukoencephalopathy, Progressive Multifocal
Virus Diseases
Viral Proteins
DNA, Viral
Simian virus 40
Astrocytes
Dicom Derivation
Neuroglia
Paper Details
References
  • References25
  • Citations16
123
  • References25
  • Citations16
12

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Derivation of a JC virus-resistant human glial cell line: implications for the identification of host cell factors that determine viral tropism

Virology

Oct 1, 2003

Gretchen V GeeW J Atwood

PMID: 14517064

DOI:

Abstract

JC virus (JCV) is a common human polyomavirus that infects 70-80% of the population worldwide. In immunosuppressed individuals, JCV infects oligodendrocytes and causes a fatal demyelinating disease known as progressive multifocal leukoencephalopathy (PML). The tropism of JCV is restrict...read more

Mentioned in this Paper

Transfection
Latent Virus Infection Process
Leukoencephalopathy, Progressive Multifocal
Virus Diseases
Viral Proteins
DNA, Viral
Simian virus 40
Astrocytes
Dicom Derivation
Neuroglia

Similar Papers Found In These Feeds

Progressive Multifocal Leukoencephalopathy (PML)

Progressive Multifocal Leukoencephalopathy (PML) occurs due to JC virus infection. While most adults are infected, PML emerges in individuals with weakened immune systems. Here is the latest on PML.

Glial Cell Differentiation

Glial cells play an essential role in maintaining brain homeostasis, forming myelin, and providing support and protection for neurons. Follow new research into glia cell differentiation with this feed.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America

Establishment of a line of human fetal glial cells that supports JC virus multiplication

Proceedings of the National Academy of Sciences of the United States of AmericaFebruary 1, 1985
E O MajorJ Sever
Paper Details
References
  • References25
  • Citations16
123
  • References25
  • Citations16
12
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