Continuation of mammalian species requires the formation and development of the sexually dimorphic germ cells. Cultured embryonic stem cells are generally considered pluripotent rather than totipotent because of the failure to detect germline cells under differentiating conditions. Here we show that mouse embryonic stem cells in culture can develop into oogonia that enter meiosis, recruit adjacent cells to form follicle-like structures, and later develop into blastocysts. Oogenesis in culture should contribute to various areas, including nuclear transfer and manipulation of the germ line, and advance studies on fertility treatment and germ and somatic cell interaction and differentiation.
Studies on the function of H-Y antigen: dissociation and reorganization experiments on rat gonadal tissue
Monoclonal antibodies to the major protein of the murine zona pellucida: effects on fertilization and early development
Oct-4 transcription factor is differentially expressed in the mouse embryo during establishment of the first two extraembryonic cell lineages involved in implantation
Progressive expression of trophoblast-specific genes during formation of mouse trophoblast giant cells in vitro
The male-specific histocompatibility antigen, H-Y: a history of transplantation, immune response genes, sex determination and expression cloning
Nuclear receptor steroidogenic factor 1 directs embryonic stem cells toward the steroidogenic lineage.
Meiotic prophase arrest with failure of chromosome synapsis in mice deficient for Dmc1, a germline-specific RecA homolog
The murine SCP3 gene is required for synaptonemal complex assembly, chromosome synapsis, and male fertility
Expression and intracellular localization of mouse Vasa-homologue protein during germ cell development
Autonomous transition into meiosis of mouse fetal germ cells in vitro and its inhibition by gp130-mediated signaling
Quantitative analysis of the hormone-induced hyperacetylation of histone H3 associated with the steroidogenic acute regulatory protein gene promoter
Bone morphogenetic protein 4 is an efficient inducer for mouse embryonic stem cell differentiation into primordial germ cell.
Stem cell-based approaches to solving the problem of tissue supply for islet transplantation in type 1 diabetes
Combined effects of Matrigel and growth factors on maintaining undifferentiated murine embryonic stem cells for embryotoxicity testing
Embryonic stem cell-derived cardiac, neuronal and pancreatic cells as model systems to study toxicological effects
Amniotic fluid stem cell-based models to study the effects of gene mutations and toxicants on male germ cell formation.
Adhesion Molecules in Health and Disease
Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.