Derivative estimation for longitudinal data analysis: Examining features of blood pressure measured repeatedly during pregnancy

Statistics in Medicine
Andrew J SimpkinKate Tilling

Abstract

Estimating velocity and acceleration trajectories allows novel inferences in the field of longitudinal data analysis, such as estimating change regions rather than change points, and testing group effects on nonlinear change in an outcome (ie, a nonlinear interaction). In this article, we develop derivative estimation for 2 standard approaches-polynomial mixed models and spline mixed models. We compare their performance with an established method-principal component analysis through conditional expectation through a simulation study. We then apply the methods to repeated blood pressure (BP) measurements in a UK cohort of pregnant women, where the goals of analysis are to (i) identify and estimate regions of BP change for each individual and (ii) investigate the association between parity and BP change at the population level. The penalized spline mixed model had the lowest bias in our simulation study, and we identified evidence for BP change regions in over 75% of pregnant women. Using mean velocity difference revealed differences in BP change between women in their first pregnancy compared with those who had at least 1 previous pregnancy. We recommend the use of penalized spline mixed models for derivative estimation in longi...Continue Reading

References

Mar 1, 1976·Archives of Disease in Childhood·J M Tanner, R H Whitehouse
Jun 15, 1976·American Journal of Obstetrics and Gynecology·R E Christianson
Nov 20, 2002·American Journal of Obstetrics and Gynecology·Helena StrevensDag Wide-Swensson
Mar 11, 2003·Diabetologia·J G ErikssonD J P Barker
Nov 30, 2004·Statistics in Medicine·M DurbánR J Carroll
Jun 3, 2009·The British Journal of Mathematical and Statistical Psychology·Jeffrey Long, Jihoon Ryoo
Dec 16, 2010·Biometrics·Huaihou Chen, Yuanjia Wang
Mar 17, 2012·Journal of Statistical Planning and Inference·Guanqun CaoDavid Todem
Apr 18, 2012·International Journal of Epidemiology·Abigail FraserDebbie A Lawlor
Sep 26, 2012·Biometrics·J GoldsmithC Crainiceanu
Feb 16, 2013·Biometrics·Sara López-Pintado, Ian W McKeague
Aug 27, 2013·American Journal of Obstetrics and Gynecology·Sarka Lisonkova, K S Joseph

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Software Mentioned

PACE
MATLAB

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.