PMID: 6249931Jul 1, 1980

Derivatives of 5-hydroxy-6-methyl-2-aminotetralin

Journal of Medicinal Chemistry
J G CannonT Verimer


The title compounds were designed to provide semirigid congeners of m-tyramine in which the ring position ortho to the phenolic OH is blocked to metabolic hydroxylation. A sequence leading to a key synthetic intermediate, 5-methoxy-6-methyl-2-tetralone, has been developed. In animal test models for dopamine-like effects, the title compounds demonstrated qualitative and quantitative differences from the isomeric 5-methyl-6-hydroxy-2-aminotetralins and from 5,6-dihydroxy-2-aminotetralins. Two of the compounds were potent in a cat cardioaccelerator nerve assay, which involves dopamine receptors.


May 18, 1984·European Journal of Pharmacology·P B TimmermansP A Van Zwieten
Apr 1, 1985·Medicinal Research Reviews·C Kaiser, T Jain
May 1, 1985·The Journal of Pharmacy and Pharmacology·H RollemaA S Horn

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