Derivatization-based High-throughput Bioanalysis by LC-MS

Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry
Toshimasa Toyo'oka

Abstract

Liquid chromatography coupled with mass spectrometry (LC-MS) is one of the most prominent analytical techniques due to its inherent selectivity and sensitivity. LC-MS is currently the first choice for high-throughput bioanalysis due to the advancements in MS instruments and the analytical software. Based on this situation, we are developing various types of derivatization reagents, including chiral reagents for MS and/or MS/MS detection. These developed reagents are adopted for the detection of biomarker candidates related to diseases. The biomarker candidates include not only achiral molecules, but also chiral ones. Although determining the already-identified chiral molecules is relative easy, it is very difficult to identify and/or determine unknown enantiomer(s) in real samples. To solve this difficulty, we proposed a new strategy to identify unknown enantiomeric biomarkers related to diseases. This review paper deals with the development of derivatization reagents for amines and carboxylic acids in LC-MS analysis and their application to bioanalysis.

References

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Citations

Dec 26, 2018·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Yukiko HorieTatsuya Higashi
Mar 25, 2019·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Sonali JainPinaki Sengupta
Dec 12, 2017·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Naoko Inoue
Aug 14, 2018·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Zhen ChenNorihiro Nishimura
May 11, 2018·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Yong MengBo-Zhong Mu
Oct 12, 2018·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Naoyuki YasakaNaotaka Kuroda
Nov 19, 2019·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Shigeaki Morita
Jun 5, 2018·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Hiroaki OkabeShu-Ping Hui
Oct 12, 2018·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Naoya Kishikawa
May 21, 2019·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Manish Kumar SharmaPinaki Sengupta
Feb 13, 2018·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Masahito ItoKiyoharu Nakatani
Apr 13, 2018·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Kenichiro TodorokiToshimasa Toyo'oka
Aug 14, 2019·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Yusuke Morisawa
Oct 22, 2020·Biomedical Chromatography : BMC·Victor DavidToma Galaon
May 18, 2021·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Weilin ShenToshiro Matsui

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