PMID: 16867717Jan 1, 1984

Derivatization reactions in the gas-liquid chromatographic analysis of drugs in biological fluids

Journal of Pharmaceutical and Biomedical Analysis
A Hulshoff, H Lingeman

Abstract

Alkylation, acylation, silylation and other derivatization reactions applied to the gas chromatographic analysis of drugs in biological matrices are reviewed. Reaction conditions are discussed in relation to reaction mechanisms. Detector-oriented labelling of drugs, and derivatization with chiral reagents for the separation of enantiomers are surveyed. Data on the sample clean-up, derivatization and GLC analysis of more than 300 drugs and related compounds are listed.

References

Jan 11, 1978·Journal of Chromatography·L T SennelloJ W Borcherding
Mar 1, 1978·Journal of Pharmaceutical Sciences·A P de Leenheer, C F Gelijkens
Oct 19, 1979·Journal of Chromatography·E W BachmannP G Waser
Feb 1, 1977·The British Journal of Psychiatry : the Journal of Mental Science·D L MurphyR J Wyatt
Nov 21, 1978·Journal of Chromatography·O Gyllenhaal, A Albinsson
Mar 1, 1979·Journal of Pharmaceutical Sciences·C SchmittB Plazonnet
Sep 1, 1979·Journal of Pharmaceutical Sciences·K KurataK Yoshida
May 1, 1979·Journal of Chromatography·H RoseboomR Bouwman
Dec 1, 1979·Journal of Pharmaceutical Sciences·S R Sun, M J Leveque
Nov 7, 1979·Journal of Chromatography·U Bondesson, P Hartvig
Jul 1, 1979·Journal of Chromatography·A P de Leenheer, M C Cosyns-Duyck
Jul 1, 1979·Journal of Chromatography·A S Christophersen, K E Rasmussen
May 1, 1978·Journal of Pharmaceutical Sciences·E RedalieuW E Wagner
Jun 1, 1978·Journal of Pharmaceutical Sciences·M T RosseelM Claeys
Aug 1, 1978·Journal of Pharmaceutical Sciences·H P Gelbke, H J Schlicht
Jul 21, 1978·Journal of Chromatography·S E SwezeyP J Meffin
Nov 1, 1978·Journal of Pharmaceutical Sciences·S R Sun, D J Hoffman
Nov 21, 1978·Journal of Chromatography·L J Dusci, L P Hackett
Mar 1, 1977·Journal of Chromatography·J GordosP Spring
May 1, 1977·Analytical Chemistry·J M RosenfeldM Kawai
Oct 1, 1977·Journal of Chromatographic Science·I A Blair, G Phillipou
May 1, 1976·Journal of Pharmaceutical Sciences·L Neelakantan, H B Kostenbauder
Jul 21, 1976·Journal of Chromatography·N NoseA Watanabe
Feb 13, 1981·Journal of Chromatography·S F Cooper, Y D Lapierre
Jun 8, 1984·Journal of Chromatography·E J RandinitisA W Kinkel
Oct 14, 1983·Journal of Chromatography·R NishiokaS Toyoda
Nov 13, 1981·Journal of Chromatography·A Sioufi, F Pommier
Apr 13, 1984·Journal of Chromatography·E J RandinitisT D Parker
Jul 8, 1983·Journal of Chromatography·M R Holdiness, L R Morgan
Sep 1, 1983·Journal of Pharmaceutical Sciences·P M BélangerG Labrecque
Nov 11, 1983·Journal of Chromatography·A SioufiP Mangoni
Nov 25, 1983·Journal of Chromatography·G P CartoniF Rosati
Feb 10, 1984·Journal of Chromatography·S C Bhatia, V D Shanbhag
Feb 1, 1984·Journal of Pharmaceutical Sciences·J P ClozelJ G Besner
Apr 6, 1984·Journal of Chromatography·H L HendricksN H Booth
Feb 13, 1981·Journal of Chromatography·B A Davis, A A Boulton
Feb 11, 1983·Journal of Chromatography·T NiwaT Ohki
Apr 8, 1983·Journal of Chromatography·L HartmannJ P Ambert
Apr 8, 1983·Journal of Chromatography·R M Matarese, C Zamponi
May 13, 1983·Journal of Chromatography·K KobayashiT Nagatsu
Jul 11, 1980·Journal of Chromatography·N van den Bosch, D de Vos
Apr 30, 1982·Journal of Chromatography·Y MatsukiH Ono
Mar 12, 1982·Journal of Chromatography·T OhkiK Maeda
Apr 16, 1982·Journal of Chromatography·H WatanabeN Ogawa
Apr 1, 1982·Psychological Reports·T SchillD Bekker
Apr 30, 1982·Journal of Chromatography·S E BarrowI A Blair
Apr 30, 1982·Journal of Chromatography·J C CraigT L Nguyen
Jun 11, 1982·Journal of Chromatography·K MatsumuraM Hirobe
May 28, 1982·Journal of Chromatography·M Polgár, L Vereczkey
Sep 10, 1982·Journal of Chromatography·R M WardB L Mirkin
Nov 12, 1982·Journal of Chromatography·B MarchesiniM B Mantovani
Dec 3, 1982·Journal of Chromatography·A I Krylov, N S Khlebnikova
Dec 12, 1980·Journal of Chromatography·K OhyaM Sano
Dec 12, 1980·Journal of Chromatography·R M GorsenR W Manthei
Mar 13, 1981·Journal of Chromatography·A SioufiJ P Metayer
Mar 13, 1981·Journal of Chromatography·P H Degen, M Ervik
Mar 13, 1981·Journal of Chromatography·N E Larsen, K Marinelli
May 1, 1981·Journal of Pharmaceutical Sciences·J B FourtillanP Courtois
May 8, 1981·Journal of Chromatography·T MaedaM Hashimoto
Jun 12, 1981·Journal of Chromatography·E MussiniF Marcucci
Nov 13, 1981·Journal of Chromatography·A B JonesC E Turner
Jan 11, 1980·Journal of Chromatography·P HartvigO Gyllenhaal
Mar 21, 1980·Journal of Chromatography·S Dilli, D Pillai
Mar 14, 1980·Journal of Chromatography·J B Whitlam, J H Vine
Jun 13, 1980·Journal of Chromatography·J Zuidema, H Hilbers
Aug 8, 1980·Journal of Chromatography·L M Ross-LeeJ H Tyrer
Sep 12, 1980·Journal of Chromatography·P J Meffin, K J Smith
Oct 1, 1980·Journal of Pharmaceutical Sciences·M GuerretJ R Kiechel
Nov 14, 1980·Journal of Chromatography·J L ChabardJ A Berger
Jan 1, 1983·Journal of Pharmaceutical and Biomedical Analysis·A HulshoffB Rook

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