Derived neutrophil lymphocyte ratio is predictive of survival from intermittent therapy in advanced colorectal cancer: a post hoc analysis of the MRC COIN study

British Journal of Cancer
T GrenaderJohn Bridgewater

Abstract

The phase III COntinuous or INtermittent (COIN) trial failed to show non-inferiority of intermittent compared with continuous chemotherapy for advanced colorectal cancer in overall survival (OS). The present analysis evaluated whether the derived neutrophil to lymphocyte ratio (dNLR) could predict the effect of intermittent vs continuous chemotherapy on OS in patients with advanced colorectal cancer. A post hoc exploratory analysis of COIN arms A and C was performed. Landmark analysis was conducted on all patients with available WBC and neutrophils data. The dNLR was calculated using a formula which has previously demonstrated predictive power in cancer patients: dNLR = ANC/(WBC-ANC). A high dNLR was defined using a cut-off value of ⩾ 2.22. Derived neutrophil to lymphocyte ratio was then correlated with clinical outcomes. Survival curves were generated based on dNLR using the Kaplan-Meier method. Comparison between groups was performed using Cox regression. A total of 1630 patients were assigned to the continuous (N = 815) or intermittent (N = 815) arms. There was a strong association between dNLR level and OS. The median survival times in the ITT population were 18.6 months and 12.5 months for patients with low and high dNLR, ...Continue Reading

References

Aug 25, 2005·Journal of Surgical Oncology·S R WalshN J Keeling
Jul 26, 2012·British Journal of Cancer·M J ProctorS J Clarke
Sep 13, 2013·The New England Journal of Medicine·Jean-Yves DouillardScott D Patterson
Feb 18, 2014·International Journal of Clinical Oncology·Ahmet DiricanMustafa Oktay Tarhan
May 31, 2014·Journal of the National Cancer Institute·Arnoud J TempletonEitan Amir

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Citations

Aug 26, 2016·Immunological Reviews·Louise W TreffersHanke L Matlung
Jun 18, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yanjuan XiongXiubao Ren
Jun 1, 2018·The FEBS Journal·Merav E Shaul, Zvi G Fridlender
Oct 16, 2018·Journal of Clinical Laboratory Analysis·Shuaishuai ChenJun Li
Jun 5, 2019·Nature Reviews. Clinical Oncology·Merav E Shaul, Zvi G Fridlender
Aug 12, 2017·Gastroenterology Research and Practice·Jue-Rong FengJin Li
Sep 29, 2020·Frontiers in Oncology·Byung Min LeeIk Jae Lee
Mar 6, 2021·Journal of Cellular and Molecular Medicine·Hao SuBo Feng
Feb 13, 2021·Veterinary and Comparative Oncology·Gonçalo N PetrucciJoaquim Henriques
Jul 21, 2021·Journal of Basic and Clinical Physiology and Pharmacology·Oktay BulurMetin Uzman
Nov 30, 2018·Chemical Reviews·Bernhard EnglingerWalter Berger
Nov 23, 2021·Annals of Surgical Oncology·Tomoki AbeYoshihiro Kakeji
Jan 14, 2022·Nature Reviews. Gastroenterology & Hepatology·Daniel GehDerek A Mann

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