Deriving components of genetic variance for multilocus models

Genetic Epidemiology
H K Tiwari, R C Elston

Abstract

Several authors have considered two-locus models as a basis for the inheritance of complex diseases. The purpose of this paper is to give a simple general formulation to derive the additive, dominant, and epistatic effects, and hence the corresponding variance components, for any multilocus model. These variance components should be useful for investigating the power of model-free linkage analysis to detect various modes of multilocus inheritance.

References

Jan 1, 1992·Genetic Epidemiology·R J Neuman, J P Rice
Jan 1, 1989·Genetic Epidemiology·D A Greenberg, S E Hodge
Jul 1, 1959·Proceedings of the National Academy of Sciences of the United States of America·K Kojima

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Citations

Feb 18, 2010·Statistics in Biopharmaceutical Research·Minghui WangHeping Zhang
Sep 28, 2006·PLoS Genetics·David M EvansLon R Cardon
Dec 1, 2007·Proceedings of the National Academy of Sciences of the United States of America·Xiang ChenHeping Zhang
May 11, 2005·Journal of Theoretical Biology·Phil Hanlon, Andy Lorenz
Jan 16, 2002·American Journal of Human Genetics·Robert CulverhouseTheodore Reich
Mar 29, 2005·Nature Genetics·Jonathan MarchiniLon R Cardon
Jan 1, 2015·Journal of the American Statistical Association·Bo Jiang, Jun S Liu

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