PMID: 7539704Jun 1, 1995Paper

Dermabrasive scar revision. Immunohistochemical and ultrastructural evaluation

Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]
C B HarmonD G Brodland

Abstract

Dermabrasion of facial scars 4-8 weeks after injury frequently completely eliminates visible evidence of scar formation. However, efforts to define the cellular and structural mechanisms by which this phenomenon occurs have been limited in their success. We investigated wound healing after dermabrasive scar revision. The surgical scars of seven patients were abraded 6-8 weeks after injury. Comparative electron microscopic and immunohistochemical studies were performed on punch biopsy specimens taken before and after the dermabrasion. Ultrastructural changes in the basement membrane components and dermal structures were evaluated. Monoclonal antibody staining techniques were used to observe the presence, location, and temporal expression of tenascin, epiligrin, cadherins, and integrin subunits. We observed: 1) an increase in collagen bundle density and size with a tendency toward unidirectional orientation of fibers parallel to the epidermal surface, 2) an upregulation of tenascin expression throughout the papillary dermis, and 3) expression of alpha-6/beta-4 integrin subunit on the keratinocytes throughout the stratum spinosum. The mechanisms by which dermabrasive scar revision alters the events of primary cicatrix formation in...Continue Reading

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Citations

Jul 2, 1998·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·K S NehalR Ashinoff
Mar 15, 2005·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Adam M RotundaTeresa T Soriano
May 23, 1998·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·J M Grevelink, V R White
Nov 28, 2016·Facial Plastic Surgery Clinics of North America·Kofi Derek Boahene, James A Owusu

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