Dermal absorption of the insecticide lindane (1 delta, 2 delta, 3 beta, 4 delta, 5 delta, 6 beta-hexachlorocyclohexane) in rats and rhesus monkeys: effect of anatomical site.

Journal of Toxicology and Environmental Health
R P Moody, L Ritter

Abstract

Dermal absorption of the insecticide lindane (1 delta, 2 delta, 3 beta, 4 delta, 5 delta, 6 beta-hexachlorocyclohexane) was determined in rats and rhesus monkeys. Lindane is in widespread use as a 1% cream or lotion scabicide formulation and as a 1% miticide shampoo for body lice control in humans. Results obtained following our in vivo dermal absorption procedure demonstrated that 18 +/- 4.1%, 34 +/- 5.2%, and 54 +/- 26.3% of the applied dose was absorbed following topical applications at a rate of 1.5 micrograms/cm2 (6.2 micrograms/100 microliters of acetone) of the 14C-labeled pesticide to 4.2-cm2 regions of the forearm (n = 8), forehead (n = 7), and palm (n = 4) of rhesus monkeys, respectively. Dose sites were washed with soapy water 24 h posttreatment. Comparative studies in rats (n = 5) dosed middorsally demonstrated 31 +/- 9.5% absorption. Statistical analysis of the 14C excretion kinetics demonstrated slower clearance of lindane from rats than monkey forearm, forehead, or palm. Intramuscular (im) injections of 14C-lindane gave 52 +/- 7.1% recovery in monkey (n = 8) and 64 +/- 5.9% in rats (n = 5), suggesting body storage of this lipophilic chemical.

References

May 1, 1977·The Journal of Investigative Dermatology·L M SolomonA M Becker
Jul 1, 1977·Toxicology and Applied Pharmacology·J H WedigH I Maibach
Jan 1, 1986·International Archives of Occupational and Environmental Health·S K NigamB B Chatterjee
Nov 1, 1986·Journal of the American Academy of Dermatology·D TaplinJ A Chen
Mar 1, 1987·The Pediatric Infectious Disease Journal·J G BowermanD E Wold
Jun 1, 1987·The Pediatric Infectious Disease Journal·J R Reeves
Aug 1, 1987·Archives of Dermatology·J E Rasmussen
Sep 1, 1987·Journal of Pediatric Health Care : Official Publication of National Association of Pediatric Nurse Associates & Practitioners·M Sanford-Driscoll
Mar 1, 1988·Archives of Dermatology·L M Solomon
Jan 1, 1988·Food Additives and Contaminants·M DagornP Sanders
Mar 1, 1985·Bulletin of Environmental Contamination and Toxicology·S Ramamoorthy
Jan 1, 1988·Journal of Toxicology and Environmental Health·E W SidonC A Franklin
Jan 1, 1987·Journal of Toxicology and Environmental Health·R P Moody, C A Franklin
May 1, 1970·The Journal of Investigative Dermatology·R J Feldmann, H I Maibach
Apr 1, 1974·Toxicology and Applied Pharmacology·R J Feldmann, H I Maibach
Jun 1, 1969·Archives of Environmental Health·B B Shugaev

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Citations

Jun 5, 2002·Chemico-biological Interactions·Torka S Poet, James N McDougal
Jul 1, 1992·Journal of Toxicology and Environmental Health·R P MoodyH I Maibach
Jul 24, 2001·Drugs·T C RoosD R Bickers
Dec 5, 2012·ISRN Dermatology·Sophie Mac-MaryPhilippe Humbert
Jan 1, 1989·Journal of Toxicology and Environmental Health·R P MoodyL Ritter
Jan 14, 1998·Human & Experimental Toxicology·I P DickF M Williams

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