Dermal adipocytes and hair cycling: is spatial heterogeneity a characteristic feature of the dermal adipose tissue depot?

Experimental Dermatology
Ilja L Kruglikov, Philipp E Scherer

Abstract

Adipocytes are widely distributed in the dermis, in a unique fat depot referred to as dermal white adipose tissue (dWAT). In rodents, dWAT is present as widespread thin layers, whereas in pigs and humans, it is present in clusters referred to as 'dermal cones' around the pilosebaceous units. This distinct layer of fat cells located above the subcutaneous white adipose tissue is important for proper hair follicle (HF) cycling in rodents. Murine HFs produce spatially restricted synchronous patches after their second postnatal cycle which correlates with the spatial heterogeneity of murine dWAT. Similarly, the cycling of HFs in humans may also be related to the spatial distribution of dWAT, making the difference between murine and human HF cycling of more quantitative than of qualitative nature. This should allow the production of small spatially correlated HF patches in human skin, and we propose that this process can be regulated by paracrine signalling involving a number of signalling modules, including the hedgehog pathway. This pathway is an established player in HF cycling, but is also involved in the regulation of adipogenesis and may therefore be a key regulator of the process across species. We also suggest that the spati...Continue Reading

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Citations

Jan 13, 2017·Nature Reviews. Rheumatology·John Varga, Roberta G Marangoni
Feb 1, 2017·Current Rheumatology Reports·Ilja L Kruglikov
Apr 20, 2017·Experimental Dermatology·Chao-Chun YangYau-Sheng Tsai
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Nov 27, 2019·Experimental Dermatology·Ilja L Kruglikov, Philipp E Scherer
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Mar 13, 2020·Dermatology : International Journal for Clinical and Investigative Dermatology·Khosrow Siamak HouschyarDominik Duscher

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