Sep 1, 1977

Dermal and glomerular deposition of IgA in anaphylactoid purpura

American Journal of Diseases of Children
J Giangiacomo, C C Tsai


During the period of acute anaphylactoid purpura, skin biopsies were performed on 14 patients with purpuric and nonpurpuric skin. In addition, four patients had renal biopsies. Examination of the tissue by immunofluorescence to anti-human immunoglobulins IgG, IgA, IgM, and IgE, fibrin/fibrinogen, complement Clq, C4, and C3 demonstrated predominant IgA, C3, fibrin/fibrinogen in the purpuric skin and glomerulus, without Clq and C4. These immunohistochemical findings are characteristic of anaphylactoid purpura and suggest that IgA is involved in the pathogenesis of anaphylactoid purpura and may operate through the alternate pathway of the complement system.

  • References
  • Citations22


  • We're still populating references for this paper, please check back later.

Mentioned in this Paper

Pathogenic Aspects
Immunofluorescence Assay
Fibrin Measurement
Complement C3 precursor
Fibrinogen Assay
Purpura Hemorrhagica
Renal Glomerular Disease

About this Paper

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Bone Marrow Neoplasms

Bone Marrow Neoplasms are cancers that occur in the bone marrow. Discover the latest research on Bone Marrow Neoplasms here.

Related Papers

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
Sunit JariwalaJenny Shliozberg
Pediatrics International : Official Journal of the Japan Pediatric Society
Yoichiro IshiiAkihiro Morikawa
Dermatology : International Journal for Clinical and Investigative Dermatology
T KobayashiS Kurihara
© 2020 Meta ULC. All rights reserved