Dermal glycosaminoglycans characterise the primary irritant dermatitis in psoriatics and healthy individuals

Clinica Chimica Acta; International Journal of Clinical Chemistry
J H Poulsen, M K Cramers

Abstract

Primary irritant dermatitis includes an inflammatory process of connective tissue which is of general interest. For the first time this process has been characterised biochemically in humans by following the dermal changes in the concentration of hydroxyproline and four glycosaminoglycans. In healthy individuals (n = 7) and in psoriatics (n = 8) the changes were rather similar. Only dermatan sulphate showed a tendency towards an abnormal response in the psoriatics. In both groups the deviations from the pre-irritant condition clearly distinguished the response of irritant dermatitis from that of the wound healing process: (1) the concentration of hyaluronic acid decreased by the third day and remained so until by the sixth day, (2) after a decrease on the third day the concentration of dermatan sulphate returned to the initial value by the sixth day, (3 and 4) the concentration of chondroitin 4/6-sulphate and heparan sulphate increased continuously from the third to the sixth day, and (5) the concentration of hydroxyproline remained constant throughout the period of investigation.

References

Nov 1, 1982·Scandinavian Journal of Clinical and Laboratory Investigation·J H Poulsen, M K Cramers
Nov 1, 1982·The British Journal of Dermatology·J H Poulsen, M K Cramers
Jun 1, 1981·Scandinavian Journal of Clinical and Laboratory Investigation·J H Poulsen
Nov 17, 1955·The New England Journal of Medicine·J E DUNPHY, K N UDUPA

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Citations

Jan 1, 1994·Progress in Histochemistry and Cytochemistry·R TammiM Tammi
Feb 7, 2013·The British Journal of Dermatology·J P McFaddenI Kimber
Jan 1, 1990·Medical Hypotheses·O J Stone
Mar 1, 1986·The Journal of Dermatologic Surgery and Oncology·O J Stone
Jun 1, 1985·The British Journal of Dermatology·A LundinG Michaëlsson
Mar 1, 1986·International Journal of Dermatology·O J Stone
Dec 11, 2002·Clinical and Experimental Dermatology·D IoannidouA Tosca
Jul 29, 1988·Journal of Chromatography·C KodamaZ Yosizawa

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