PMID: 7035526Feb 1, 1982Paper

Dermal hypersensitivity reactions to insulin: correlations of three patterns to their histopathology

The Journal of Allergy and Clinical Immunology
R D deShazoH F Dvorak

Abstract

Fifteen diabetics with recurrent painful local reactions to insulin were studied. Reactions occurring after intradermal insulin injection were observed in nine patients over 48 hr and biopsies were taken at intervals for microscopic study using the 1 mu Giemsa technique. Insulin-specific IgE and IgG levels were measured on all patients. Five patients had biphasic reactions in which wheal and flare (WFR) were followed by an indurated lesion 4 to 6 hr later. These reactions lasted up to 24 hr and were histopathologically identical to similar "late-phase reactions" seen with ragweed. They were transferable with Prausnitz-Küstner (P-K) testing. Three patients had reactions that developed 8 to 12 hr after injection, peaked around 24 hr, and were not preceded by WFR. These reactions were morphologically delayed hypersensitivity reactions and were not transferred by P-K testing. One patient had a reaction that developed in 4 to 6 hr after injection and peaked by 12 hr. Histologically, this reaction was "Arthus" in type and was not transferred by P-K testing. Specific insulin antibody determinations were not helpful in distinguishing patients with different types of reactivity. These data show that recurrent local reactions to insulin ...Continue Reading

Citations

Apr 25, 2008·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·I Leonard BernsteinUNKNOWN American College of Allergy, Asthma and Immunology
Feb 7, 2001·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·M B Lierl
Aug 21, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·H Froehlich, R Verma
Dec 21, 2004·Diabetic Medicine : a Journal of the British Diabetic Association·U Bodtger, M Wittrup
Jun 1, 1995·Journal of Cutaneous Pathology·A M Morgan
Apr 5, 1986·British Medical Journal·P Silverstone
Sep 26, 2003·American Journal of Clinical Dermatology·Tristan Richardson, David Kerr
Apr 19, 2011·Clinics in Dermatology·Mohammad K Ghazavi, Graham A Johnston
Oct 1, 1988·The Journal of Allergy and Clinical Immunology·J DolovichF E Hargreave
May 12, 2017·JFMS Open Reports·Lisa A MurphyPaul Gambardella
Jan 12, 2007·Diabetes/metabolism Research and Reviews·R P Radermecker, A J Scheen
Sep 1, 1983·International Journal of Dermatology·R F Lemanske, M A Kaliner
Sep 6, 2007·Endocrine Reviews·S Edwin FinebergAlan S Krasner
Mar 7, 2017·Journal of Diabetes Science and Technology·Anneke GrafDavid N O'Neal
Aug 29, 1998·Allergy·R CabañasP Barranco
Mar 25, 2017·Journal of General Internal Medicine·Benjamin R MurrayPoonam Sharma
Jul 31, 2021·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Babak Aberumand, Samira Jeimy

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