Dermal matrix as a carrier for in vivo delivery of human adipose-derived stem cells

Biomaterials
A M AltmanE U Alt

Abstract

The aim of the present study was to evaluate the potential of acellular dermal matrix as a carrier for delivery of stem cells to the site of soft tissue defect in a murine skin injury model and to determine the potential of stem cells delivered via such an approach to successfully engraft, survive and differentiate locally. We showed that adipose-derived stem cells delivered via this matrix survived after in vivo engraftment, spontaneously differentiated along vascular endothelial, fibroblastic and epidermal epithelial lineages and significantly improved wound healing. Furthermore, an organ survey for transplanted cells showed no evidence of a systemic distribution beyond the cutaneous wound site, indicating that the adipose-derived stem cell-dermal matrix construct provides a novel and effective method for anatomically focused cellular therapy. In conclusion, stem cell-seeded dermal matrix is an effective means for targeted in vivo cell delivery for enhanced soft tissue regeneration.

References

Dec 12, 2002·Molecular Biology of the Cell·Patricia A ZukMarc H Hedrick
Jan 22, 2004·Biochemical and Biophysical Research Communications·Kristine G GaustadPhilippe Collas
Apr 13, 2004·Nature Biotechnology·Catherine M CowanMichael T Longaker
May 18, 2004·Burns : Journal of the International Society for Burn Injuries·Gulsun Erdag, Robert L Sheridan
Jun 9, 2004·Journal of Pediatric Surgery·Julie R FuchsDario O Fauza
Jun 4, 2005·Diseases of the Colon and Rectum·Damián García-OlmoJosé Antonio Rodríguez-Montes
Apr 4, 2006·Nature Medicine·Yoshinori MiyaharaHidezo Mori
Jul 1, 2006·Nature·David T Scadden
Aug 24, 2006·Transplantation·Herman BlomeierWilliam L Lowe
Aug 29, 2006·Plastic and Reconstructive Surgery·Timothy A MoseleyMarc H Hedrick
Feb 6, 2007·Biochemical and Biophysical Research Communications·Yao-Hua SongEckhard Alt
Jun 29, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Agnieszka BanasTakahiro Ochiya

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Citations

Mar 19, 2011·Aesthetic Plastic Surgery·Hakan OrbayHiroshi Mizuno
Apr 28, 2009·Archives of Dermatological Research·Won-Serk KimJong-Hyuk Sung
Mar 3, 2011·Archives of Dermatological Research·T Hodgkinson, A Bayat
Feb 15, 2014·Advances in Wound Care·Susan W VolkArdeshir Bayat
May 14, 2010·Plastic and Reconstructive Surgery·Andrew M AltmanCharles E Butler
Jan 14, 2011·Plastic and Reconstructive Surgery·Sae Hee KoMichael T Longaker
Jul 24, 2013·Journal of Biomedical Science·Sheng-Ping HuangShih-Ming Huang
Nov 20, 2012·Indian Journal of Plastic Surgery : Official Publication of the Association of Plastic Surgeons of India·Ramesh Kumar Sharma, Jerry R John
May 3, 2014·Annals of Biomedical Engineering·Michael S HuH Peter Lorenz
Jan 5, 2011·Annals of Plastic Surgery·Mario CherubinoKacey G Marra
Jul 22, 2014·The Journal of Dermatological Treatment·Zeinab A IbrahimMohamed El Afandy
Oct 30, 2015·International Journal of Molecular Sciences·Nkemcho OjehOlivera Stojadinovic
Sep 16, 2009·Expert Review of Medical Devices·Maria Cristina Tanzi, Silvia Farè
Jun 4, 2015·Expert Opinion on Biological Therapy·Yoshiaki ShingyochiHiroshi Mizuno
Jun 15, 2012·Biomaterials·Fa-Ming ChenQing Yu
Jun 27, 2012·Clinics in Plastic Surgery·Sadanori AkitaShunichi Yamashita
Dec 29, 2015·Plastic and Reconstructive Surgery·Mustafa Aykut OzpurSuleyman Kaplan
Feb 4, 2016·Stem Cells International·Bommie Florence Seo, Sung-No Jung
Jul 7, 2010·Biochemical and Biophysical Research Communications·Sebastian GehmertYao-Hua Song
Aug 4, 2015·Acta Biomaterialia·Yang ZengRobert Chunhua Zhao
Sep 2, 2009·Experimental Dermatology·Katherine LauArdeshir Bayat
Jun 30, 2012·Experimental Dermatology·Victor W Wong, Geoffrey C Gurtner
Oct 14, 2011·Macromolecular Bioscience·Victor W WongGeoffrey C Gurtner
Feb 27, 2010·Journal of Biomedical Materials Research. Part a·Vishal GuptaAnshu B Mathur
Mar 19, 2014·Biopolymers·Sayani Chattopadhyay, Ronald T Raines
Oct 6, 2012·Journal of Tissue Engineering and Regenerative Medicine·Chunlei NieJiewu Zhang
Jul 12, 2012·Journal of Tissue Engineering and Regenerative Medicine·Dong Won LeeDae Hyun Lew
Oct 29, 2015·BioMed Research International·Francesco Piraino, Šeila Selimović
Sep 12, 2015·International Journal of Inflammation·Rodrigo G RosiqueJayme A Farina Junior
Apr 3, 2014·Annals of Plastic Surgery·Navid Mohamadpour ToyserkaniJens Ahm Sørensen
Jun 25, 2015·Stem Cells International·M IsaksonA J P Clover
Apr 15, 2016·Advances in Wound Care·Mariana Teixeira CerqueiraAlexandra Pinto Marques

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