Dermal peptide delivery using enhancer molecules and colloidal carrier systems. Part III: Tetrapeptide GEKG

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
Elfi SommerJ Wohlrab

Abstract

Dermal application of peptides as drugs is an interesting and growing field in therapeutics. Besides therapy, they are increasingly used as cosmetic agents. Peptide delivery into the skin is highly challenging since they provide disadvantageous properties like a high molecular weight, hydrophilicity, polarity and susceptibility to enzymatic degradation. The aim of the presented study was to improve the bioavailability of a dermal administered tetrapeptide GEKG (amino acid sequence in one-letter notation). A nano-sized carrier system (microemulsion, ME) of w/o type was therefore developed since ME provide excellent penetration enhancing properties. Furthermore, enhancers were used to increase the penetration capacity of GEKG. The penetration of GEKG from the ME and enhancer-containing emulsions was compared to the penetration from a standard formulation. For this purpose ex vivo penetration studies with human skin were performed, which provide insights into dermal penetration and also localization and distribution of the active substances in each skin layer as well as the influence of vehicle variations. Experiments with three incubation times (30, 100, 300 min) and 5000 ppm GEKG in the formulations clearly show that the nano-si...Continue Reading

Citations

Nov 13, 2019·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·Johannes Wohlrab
Dec 4, 2019·Journal of Peptide Science : an Official Publication of the European Peptide Society·Ga-Hee HurMi-Young Lee
Nov 17, 2020·Frontiers in Chemistry·Fosca ErranteAnna Maria Papini
Apr 13, 2021·Advanced Drug Delivery Reviews·Dongmei CunMingshi Yang
Dec 28, 2021·Pharmaceutical Development and Technology·Mengyang LiuJingyuan Wen

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