PMID: 3754616Mar 1, 1986Paper

Dermal prostacyclin, thromboxane A2 and prostaglandin F2 alpha in climacteric women: effect of oestrogen replacement therapy

Maturitas
J PuolakkaOlavi Ylikorkala

Abstract

The involvement of dermal prostanoids in menopausal flushing was studied in 8 women suffering from climacteric hot flushes and in 10 asymptomatic control subjects by inducing suction blisters on abdominal skin and assaying blister fluids for 6-keto-PGF1 alpha, a metabolite of the vasodilative prostacyclin (PGI2), thromboxane B2 (TxB2), a metabolite of the vasoconstrictive thromboxane A2 (TxA2), and 13,14-dihydro-15-keto-PGF2 alpha (M-PGF2 alpha), a metabolite of prostaglandin F2A (PGF2A). No marked differences were observed in the levels of these prostanoids in the two study groups. The women experiencing flushes then received conjugated oestrogens for 3 mth to abolish vascular instabilities. This decreased the blister fluid concentration of M-PGF2 alpha from 1720 +/- 476 pg/ml (mean +/- SE) to 1490 +/- pg/ml (P less than 0.05), but had no effect on the dermal levels of 6-keto-PGF1 alpha or TxB2. It was concluded that although certain dermal prostanoids may be affected by oestrogen treatment they are not of primary significance as regards menopausal flushing.

References

May 17, 1979·The New England Journal of Medicine·S Moncada, J R Vane
Oct 1, 1977·British Journal of Obstetrics and Gynaecology·S ChakravartiJ W Studd
Feb 23, 1980·Lancet·C R StrakoschH Keen
Apr 4, 1981·Lancet·W S Phillips, S L Lightman
Nov 1, 1984·British Journal of Obstetrics and Gynaecology·M BrincatJ W Studd
Oct 1, 1980·Prostaglandins·L Viinikka, O Ylikorkala

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