Dermatitis herpetiformis: immune complex detection with C1q and monoclonal rheumatoid factor

The British Journal of Dermatology
R E JordonK Wolff


To determine the significance of circulating immune complexes in dermatitis herpetiformis, serum samples from thirty patients with active disease were tested by a C1q binding radioassay, while serum samples from twenty-one of these patients were tested by a monoclonal rheumatoid factor (mRF) inhibition radioassay. By direct immunofluorescence, all patients demonstrated typical IgA deposition in dermal papillae. Using the C1q binding assay, only seven of forty-two serum samples had elevated C1q binding activity, while by the mRF inhibition assay, thirteen of twenty-five samples had elevated immune complex levels. Nine of these latter thirteen positive serum samples, however, were minimally elevated. Thus, IgG and/or IgM containing immune complexes are infrequently present, or at very low levels, in sera of patients with active dermatitis herpetiformis.


Feb 1, 1978·The Journal of Investigative Dermatology·S I Katz, W Strober
Dec 1, 1979·The Journal of Clinical Investigation·S E MackelR E Jordan
Nov 1, 1974·Clinical Immunology and Immunopathology·T T Provost, T B Tomasi
Feb 1, 1974·The British Journal of Dermatology·L Fry, P P Seah
Aug 1, 1980·The Journal of Investigative Dermatology·J J ZoneT T Provost

Related Concepts

Immune complex
Complement Activating Enzymes
Dermatitis Herpetiformis
Immunofluorescence Assay
Rheumatoid Factor
Complement C1q

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