Dermatofibrosarcoma protuberans: A clinical analysis

Oncology Letters
Anqi Lyu, Qiying Wang

Abstract

Dermatofibrosarcoma protuberans (DFSP) is a rare cutaneous tumor with a high incidence of misdiagnosis. DFSP has a high rate of recurrence but a low rate of metastasis. In the present study, retrospective analyses were performed on the clinical features, differential diagnosis and treatment of patients with DFSP to improve our understanding of the disease and allow more effective treatment measures to be implemented. The present study investigated the clinicopathological features of 70 pathologically confirmed cases of DFSP at the First Affiliated Hospital of Zhengzhou University (Zhengzhou, China) between March 2012 and 2017. The primary endpoint was recurrence rate. Three cases were analyzed in detail. The results revealed that 7 of the 41 primary patients (follow-up at 2.7 years) had recurrence (17.1%), compared with 11 (37.9%) of the 29 recurrent patients (follow-up at 2.0 years, P=0.049). Of the 59 patients with DFSP (follow-up at 2.6 years), 12 had recurrence (20.3%) compared with 6 (54.6%) of the 11 patients with fibrosarcomatous DFSP (FS-DFSP; follow-up at 2.1 years, P=0.045). DFSP requires diagnosis by pathological examination, and surgical resection is the main treatment. DFSP demonstrated a high recurrence rate, with...Continue Reading

References

Apr 25, 2000·Journal of Cutaneous Pathology·J E SigelJ R Goldblum
Oct 27, 2004·Cancer·William M MendenhallMark T Scarborough
Jun 25, 2005·Journal of Clinical Pathology·Z Szollosi, Z Nemes
Apr 19, 2007·Plastic and Reconstructive Surgery·Pentscho PopovErkki Tukiainen
Aug 8, 2008·Cancer Treatment Reviews·A ParadisiM Podda
Jan 29, 2011·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Luciano J Iorizzo, Marc D Brown
Feb 1, 2012·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Benjamin BoguckiEva A Hurst
Dec 25, 2012·Journal of the American Academy of Dermatology·David E KurlanderJeremy S Bordeaux
Jan 19, 2013·Seminars in Diagnostic Pathology·Beatriz LlombartOnofre Sanmartín
Aug 2, 2014·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Marie KaranianAgnès Neuville
Jan 15, 2015·Journal of the American Academy of Dermatology·Paul M HoeslyJulia S Lehman
Oct 1, 2015·Oman Medical Journal·Salim Al-RahbiKhoula Al-Harrasi
Oct 28, 2016·The Journal of Investigative Dermatology·Marcella TazzariChiara Castelli

❮ Previous
Next ❯

Citations

Mar 16, 2019·Current Treatment Options in Oncology·Takeshi IwasakiYoshinao Oda
Jun 11, 2020·Journal of Clinical Medicine·Xingpei HaoAllison T Vidimos

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete
K J KilianC Kunte
European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
M G SmolaE Scharnagl
European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
S Ten HeuvelH J Hoekstra
© 2022 Meta ULC. All rights reserved