Dermatofibrosarcoma protuberans: a report on 29 patients treated by Mohs micrographic surgery with long-term follow-up and review of the literature

Cancer
Stephen N SnowDavid B Sable

Abstract

Dermatofibrosarcoma protuberans (DFSP) is an uncommon tumor of the skin. Clinically, it often masquerades as a benign, indolent tumor on the trunk and extremities. Microscopically, it extends far beyond assessed clinical margins, spreading locally in the dermis, subcutaneous tissue, and muscle. The local recurrence rate in patients with DFSP who undergo wide local excision ranges from 0% to 21%. Recent preliminary reports indicate more consistently favorable cure rates with Mohs micrographic surgery (MMS). However, to date only a few scattered reports have documented long-term 5-year follow-up. The authors present data on 29 patients with DFSP who underwent MMS. In addition, they reviewed the medical literature to summarize the accumulated experience of MMS treatment in the management of DFSP. The authors conducted a retrospective review of a series of 40 consecutive patients with DFSP who underwent MMS over the last 20 years. Of these, there were 29 patients with > 5 years of follow-up who formed the basis of the current review. The literature also was searched for patients with DFSP who underwent MMS with > 5 years of follow-up At the University of Wisconsin Mohs Surgery Clinic, 29 patients with > 5 years of follow-up were tr...Continue Reading

References

Jan 1, 1978·The Journal of Dermatologic Surgery and Oncology·G R Mikhail, B H Lynn
Jun 1, 1985·Journal of the American Academy of Dermatology·J K Robinson
Dec 1, 1989·The Journal of Dermatologic Surgery and Oncology·M D Brown, N A Swanson
Aug 1, 1989·International Journal of Radiation Oncology, Biology, Physics·L B MarksW C Wood
May 1, 1988·The Journal of Dermatologic Surgery and Oncology·P J WeberE Gould
May 1, 1988·Cleveland Clinic Journal of Medicine·E R Hobbs, J L Ratz
Mar 1, 1985·The Journal of Dermatologic Surgery and Oncology·K A HessS J Shideler
May 1, 1966·American Journal of Surgery·B R BurkhardtJ C Ivins
Jan 1, 1983·Scandinavian Journal of Plastic and Reconstructive Surgery·K Bendix-HansenS Kaae
Mar 1, 1984·Plastic and Reconstructive Surgery·J M AbideR G Bennett
Jun 1, 1984·Archives of Otolaryngology·L BarnesJ T Johnson
Oct 1, 1982·The Journal of Dermatologic Surgery and Oncology·C W PetersJ E Bennett
Oct 1, 1994·The Journal of Dermatologic Surgery and Oncology·F J JimenezR E Clark
Apr 1, 1995·International Journal of Dermatology·C K KohE H Wyatt
Feb 1, 1995·Journal of the American Academy of Dermatology·T L Parker, J A Zitelli
May 1, 1996·Archives of Pediatrics & Adolescent Medicine·T A KahnW F Bergfeld
Sep 1, 1996·Journal of the American Academy of Dermatology·H M Gloster
Jan 1, 1996·Plastic Surgical Nursing : Official Journal of the American Society of Plastic and Reconstructive Surgical Nurses·M King, I Ocheltree
Apr 3, 1998·Archives of Otolaryngology--head & Neck Surgery·A F Haas, J M Sykes
Jul 21, 1998·Seminars in Cutaneous Medicine and Surgery·T F Cook, S W Fosko
Feb 23, 1999·Dermatology : International Journal for Clinical and Investigative Dermatology·J HafnerG Burg
Apr 25, 2000·Journal of the American Academy of Dermatology·S MadaniA Carruthers
Jun 23, 2000·Journal of the American Academy of Dermatology·R M Mondragon, T L Barrett
Jul 25, 2000·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·B D ClaytonW L White
Oct 26, 2000·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·G J KricorianR G Bennett
Dec 29, 2000·Surgical Oncology·V K SondakT M Johnson
Mar 22, 2001·Journal of the American Academy of Dermatology·M J HuetherD G Brodland
Jul 1, 1962·Cancer·H B TAYLOR, E B HELWIG
Nov 1, 1950·A.M.A. Archives of Dermatology and Syphilology·L W SHAFFER

❮ Previous
Next ❯

Citations

Jan 27, 2007·Current Oncology Reports·Thomas A Abrams, Scott M Schuetze
Jun 1, 2005·Journal of the American College of Surgeons·Kelly M McMasters
May 25, 2006·Current Opinion in Oncology·Grant A McArthur
Oct 28, 2009·American Journal of Clinical Oncology·Ari-Nareg MeguerditchianJohn M Kane
Sep 29, 2011·American Journal of Clinical Oncology·Jerry D BrewerClark C Otley
Sep 8, 2009·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Karen RiggsTatyana Humphreys
Nov 19, 2011·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·James O Barlow
Feb 1, 2012·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Benjamin BoguckiEva A Hurst
Jan 25, 2012·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·S Tyler HollmigJinah Kim
Jun 14, 2012·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Paul KuzelThomas G Salopek
Jul 19, 2012·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Kyle A Anderson, Allison T Vidimos
Jul 12, 2012·Pediatric Dermatology·Rachel I KornikJoyce M Teng
Dec 31, 2009·Obstetrics and Gynecology International·K DoufekasD Nunns
Oct 7, 2011·Journal of Medical Case Reports·Olivier CottierJean-François Delaloye
May 1, 2007·Annals of Surgical Oncology·Zebadiah KimmelMurad Alam
Jul 25, 2007·Annals of Surgical Oncology·Grant McArthur
May 3, 2008·Annals of Surgical Oncology·Jonathan S ZagerVernon K Sondak
Apr 1, 2010·Annals of Surgical Oncology·Jeffrey M FarmaVernon K Sondak
Aug 18, 2009·Journal of Neurosurgery·Austin K MattoxD Cory Adamson
Aug 3, 2013·AJNR. American Journal of Neuroradiology·G G MillareJ M Debnam
Mar 7, 2007·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Chadwick John ThomasVictor J Marks
Mar 6, 2008·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·John G HancoxHubert T Greenway
Aug 22, 2006·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Paola SavoiaMaria Grazia Bernengo
Jan 19, 2006·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Lesley Loss, Nathalie C Zeitouni
Jun 30, 2014·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Yueh-Ju TsaiYuan-Cheng Chiang
Apr 24, 2014·Journal of the American Academy of Dermatology·Christine A LiangChrysalyne D Schmults
Jan 15, 2014·Annales de chirurgie plastique et esthétique·B ChaputD Gangloff
Feb 12, 2009·Journal of Cancer Research and Clinical Oncology·Doreen LemmK Höffken
Jun 2, 2015·Expert Review of Anticancer Therapy·Piotr Rutkowski, Maria Debiec-Rychter
Jan 26, 2016·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Anastasia BenoitMariah Brown
Oct 9, 2013·Journal of the American Academy of Dermatology·C William HankeLuitgard G Wiest
Dec 30, 2015·International Journal of Dermatology·Eva Van SteenkisteSteven Pans
Jan 19, 2013·Seminars in Diagnostic Pathology·Beatriz LlombartOnofre Sanmartín
Nov 17, 2012·Actas dermo-sifiliográficas·M Valdivielso-Ramos, J M Hernanz
Jun 5, 2012·Journal of the American Academy of Dermatology·Isabel Irarrazaval, Pedro Redondo
Apr 10, 2012·Actas dermo-sifiliográficas·M Valdivielso-Ramos, J M Hernanz
Mar 6, 2012·Journal of the American Academy of Dermatology·Donald W BuckJeffrey D Wayne
Jan 31, 2012·Actas dermo-sifiliográficas·C Serra-GuillénO Sanmartín
Mar 23, 2011·Dermatologic Clinics·Leonid B Trost, Philip L Bailin
Mar 23, 2011·Dermatologic Clinics·Hillary Johnson-Jahangir, Désirée Ratner
Jun 15, 2010·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Lucas de VillalaínPablo Rosado
May 18, 2010·Annales de dermatologie et de vénéréologie·S BucheL Mortier

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