Dermatofibrosarcoma protuberans and giant cell fibroblastoma exhibit CD99 positivity

Journal of Cutaneous Pathology
A Hafeez DiwanKathleen J Smith

Abstract

According to most authors, dermatofibrosarcoma protuberans (DFSP) and giant cell fibroblastoma (GCF) represent the adult and juvenile forms, respectively, of the same disease entity, as evidenced by similar morphology, an identical chromosomal translocation, and CD34 positivity. It has been shown that DFSP and nuchal-type fibroma (NTF) (which is also CD34-positive) are related lesions, and that there might possibly be a continuum between the two. In addition, NTF exhibits CD99 positivity. It was therefore, hypothesized that both DFSP and GCF would show similar immunopositivity for CD99. Archives of pathology at several institutions were searched for DFSP and GCF tissue blocks. A total of 29 DFSP and 5 GCF were analyzed by immunohistochemistry for expression of CD99. Twenty-three of 29 DFSP (79%) and 2 of 5 GCP (40%) expressed CD99. Comparison of CD99 and CD34 showed that the non-tumoral periphery of DFSP was less probable to be CD99 positive, but this finding was not statistically significant.

References

May 1, 1988·Histopathology·F C RamaekersF Smedts
Jan 15, 1999·The American Journal of Surgical Pathology·M van de RijnC Fisher
Jan 28, 1999·Cancer·M MichalM Miettinen
Nov 15, 2000·The American Journal of Surgical Pathology·A H DiwanM G Horenstein
Apr 6, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·R D PettersenS O Lie
Jan 16, 2002·American Journal of Clinical Pathology·Carlos MonteagudoAntonio Llombart-Bosch
Jan 29, 2002·Nature Immunology·Alan R SchenkelWilliam A Muller

❮ Previous
Next ❯

Citations

May 11, 2012·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Jennifer BlackLouis P Dehner
Feb 12, 2009·Journal of Cancer Research and Clinical Oncology·Doreen LemmK Höffken
Sep 18, 2012·Journal of the American Academy of Dermatology·Lindsay A EmingerWarren R Heymann
Sep 1, 2011·Surgical Pathology Clinics·Karokh H SalihElizabeth A Montgomery
Jun 17, 2011·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·M B KarpovaR Dummer
Nov 20, 2013·The American Journal of Dermatopathology·Viktoryia KazlouskayaDirk M Elston
Aug 1, 2009·Archives of Pathology & Laboratory Medicine·Justin WassermanVesna Petronic-Rosic

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.