PMID: 8608381Feb 1, 1996Paper

Dermatofibrosarcoma protuberans treated with Mohs surgery. A case with CD34 immunostaining variability

Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]
C GarciaR E Clark

Abstract

Immunohistochemical stains for CD34 antigen can help in differentiating dermatofibrosarcoma protuberans (DFSP) from other fibrohistiocytic tumors and in demarcating its surgical margins during Mohs surgery. However, variable expression of CD34 antigen in nodular areas can sometimes result in negative staining of tissue sections creating diagnostic and therapeutic dilemmas. To show the variable expression of CD34 antigen in a DFSP tumor. Case presentation of DFSP with immunohistochemical staining using the ABC peroxidase macromolecular complex. Microscopic examination of paraffin-embedded sections showed CD34-negative DFSP tumor cells with positive staining of endothelial cells. On frozen sections at the time of surgery the tumor cells stained strongly positive for CD34. This case demonstrates the variable expression of CD34 antigen by DFSP tumors and emphasizes the need to interpret with caution the results of these immunostains during Mohs surgery.

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Citations

Jun 7, 2005·Annales de chirurgie plastique et esthétique·R BehbahaniP Pellerin
Oct 1, 1998·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·R A MasseyY D Eliezri
Apr 29, 2009·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Donald StranahanNeil A Fenske
Jan 27, 2010·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Abdel Kader El TalDavid A Mehregan
Jun 18, 2011·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Carlos Serra-GuillénCarlos Guillén
Feb 1, 2012·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Benjamin BoguckiEva A Hurst
Jul 25, 2007·Annals of Surgical Oncology·Grant McArthur
Sep 17, 2010·Annals of Surgical Oncology·Ryan C FieldsMurray F Brennan
Nov 21, 2008·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Maya K ThosaniChih-Shan Jason Chen
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Feb 18, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·Y-T ChenY-C Huang
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Dec 7, 2005·Archives of Pathology & Laboratory Medicine·Megan J Smith-Zagone, Mary R Schwartz

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