Dermatologic evaluation of cosmetic formulations containing Chrysanthemum indicum extract

Journal of Cosmetic Dermatology
Keun Taek ChoiYoung Jun Kim

Abstract

Chrysanthemum indicum, an oriental medicinal plant, has been shown to display a variety of pharmacological activities including antibacterial and anti-inflammatory effects. In this study, we evaluated the ability of C. indicum extracts to inhibit in vitro tyrosinase activity and the skin care effects of cosmetic formulations containing 0.5% C. indicum water extract in human volunteers. The formation of dopachrome from L -dopa by mushroom tyrosinase was observed after treatments with C. indicum extracts. The volunteers received placebo (no extract) or test (0.5% C. indicum water extract) cosmetic cream and applied it on their face three times a day for 6 weeks. Biophysical skin parameters were measured every 2 weeks. Chrysanthemum indicum methanol and water extracts dose dependently inhibited mushroom tyrosinase activity, and the effects of methanol extract were similar to those of kojic acid, a well-known tyrosinase inhibitor. Clinical evaluations revealed that application of cosmetic formulations containing C. indicum water extract time dependently reduced melanin levels over 6 weeks, whereas the placebo group showed no effect. No changes in moisture, elasticity, wrinkles, evenness, and pore size were observed in either group....Continue Reading

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Citations

Feb 27, 2020·Journal of Cosmetic Dermatology·Julie K NguyenJared Jagdeo

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