Dermatological indications for the use of isotretinoin beyond acne

The Journal of Dermatological Treatment
Emily ForbatF Al-Niaimi

Abstract

While the use of isotretinoin has revolutionized the treatment of acne vulgaris, isotretinoin is increasingly recognized as a useful therapeutic option for many other cutaneous conditions. We review the evidence underlying the use of isotretinoin for a variety of dermatological indications including hidradenitis suppurativa, sebaceous gland pathology, rosacea, scarring alopecia, cosmetic dermatology, and non-melanoma skin cancer prophylaxis amongst other uses, and thus consider alternative uses within dermatology practice. The studies found benefit of isotretinoin, however most trials lacked statistical power and in many cases the use was limited to case series. Isotretinoin, if used within the correct cohort with appropriate pretreatment counseling regarding side-effects, is a well-tolerated medication with potential as either an adjunctive treatment or a second-line agent in those recalcitrant cases unresponsive to first-line therapy.

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Citations

Jun 6, 2019·Anais Brasileiros De Dermatologia·Renata Ferreira MagalhãesAndrea Machado Coelho Ramos
Feb 6, 2020·Dermatologic Therapy·Ayman AbdelmaksoudMrinal Gupta
Apr 16, 2020·Journal of the European Academy of Dermatology and Venereology : JEADV·R FoleyF Powell
Sep 15, 2020·Birth Defects Research·Michael A GarlandChengji J Zhou
Jul 20, 2020·Dermatologic Therapy·Raul E Ruiz-LozanoJesus Alberto Cardenas-de la Garza
Jan 15, 2020·Actas dermo-sifiliográficas·D Morgado-CarrascoP Giavedoni

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