Dermatopathy in juvenile Angus cattle due to vitamin A deficiency

Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
Thomas J BaldwinJeffery O Hall

Abstract

In juvenile cattle, vitamin A deficiency is reported most commonly as a neurological condition; only rarely are there dermatologic manifestations. In the current study, alopecia, severe epidermal and follicular orthokeratosis, and acanthosis due to hypovitaminosis A are reported in 2 of 32 Angus calves, with a third animal suspected. Affected animals responded to vitamin A supplementation, and no additional calves displayed signs. Vitamin A acts on skin by regulating DNA transcription in keratinocytes, reducing the number of tonofilaments and desmosomes, both involved in cell-to-cell adhesion. Hence, adequate levels of dietary vitamin A are necessary for normal keratinocyte turnover, and deficiencies result in retention of keratinized cells (orthokeratosis). The present report reminds diagnosticians to consider vitamin A deficiency in cases of orthokeratotic dermatopathy in cattle.

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Citations

Nov 2, 2014·Experimental Biology and Medicine·Liye SuoHelen B Everts
Feb 23, 2021·Frontiers in Cell and Developmental Biology·Liye SuoHelen B Everts
Apr 6, 2021·Parasitology Research·Francis MutebiGeorg von Samsom-Himmelstjerna

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Methods Mentioned

BETA
biopsy

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