Dermic diffusion and stratum corneum: a state of the art review of mathematical models

Journal of Controlled Release : Official Journal of the Controlled Release Society
Ana CoutoAna M Pessoa

Abstract

Transdermal biotechnologies are an ever increasing field of interest, due to the medical and pharmaceutical applications that they underlie. There are several mathematical models at use that permit a more inclusive vision of pure experimental data and even allow practical extrapolation for new dermal diffusion methodologies. However, they grasp a complex variety of theories and assumptions that allocate their use for specific situations. Models based on Fick's First Law found better use in contexts where scaled particle theory Models would be extensive in time-span but the reciprocal is also true, as context of transdermal diffusion of particular active compounds changes. This article reviews extensively the various theoretical methodologies for studying dermic diffusion in the rate limiting dermic barrier, the stratum corneum, and systematizes its characteristics, their proper context of application, advantages and limitations, as well as future perspectives.

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Citations

Oct 28, 2015·Journal of Pharmaceutical Sciences·Danila G PetlinYuri G Anissimov
Aug 19, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jason T Chittenden, Jim E Riviere
Aug 8, 2015·BioMed Research International·Hinda DabboueGilberte Marti-Mestres
Mar 20, 2019·Biomedical Engineering Online·Michael Meyer
May 24, 2017·Drug Delivery and Translational Research·Jingjing MaZhonggui He
Oct 6, 2020·Expert Opinion on Drug Metabolism & Toxicology·Joshua J CalcuttYuri G Anissimov
May 12, 2021·AAPS PharmSciTech·Sonalika Arup BhattaccharjeeAjay K Banga
Sep 25, 2021·International Journal of Pharmaceutics·Fang DouNitin Nitin

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