Dermo-epidermal separation is associated with induced tenascin expression in human skin

The British Journal of Dermatology
S SchenkR Chiquet-Ehrismann

Abstract

Tenascin, a large glycoprotein of the extracellular matrix, shows a site-restricted distribution during embryogenesis, and can be found in adults in a variety of pathological conditions. In normal skin, tenascin is expressed at low levels, but it is upregulated in skin tumours, in a number of skin diseases with epidermal hyperproliferation and during wound healing. Several tenascin variants have been described, and these arise by alternative splicing. Using a monoclonal antibody recognizing all tenascin variants, and polyclonal antibodies specific for the large tenascin variants, we have investigated tenascin expression in bullous diseases such as epidermolysis bullosa, pemphigus, bullous pemphigoid and pemphigoid gestationis. By immunohistochemistry, we have found increased tenascin staining in all patient skin samples, with a more pronounced tenascin expression in samples of autoimmune bullous diseases. The large tenascin variants seem to be major forms of tenascin occurring in healthy skin. In patients with blistering diseases, however, these large variants appear to represent a subpopulation of the induced tenascin accumulation. These findings suggest different functions for the tenascin variants in normal and diseased skin.

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Citations

Dec 21, 2000·The British Journal of Dermatology·T K GilmourS Kossard
Sep 6, 2012·BMC Clinical Pathology·Florence BrellierRuth Chiquet-Ehrismann
Jul 8, 2003·The Journal of Pathology·Ruth Chiquet-Ehrismann, Matthias Chiquet
Feb 19, 2000·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·D D Sta IglesiaM A Stepp
Jun 17, 2000·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·L HäkkinenH Larjava
Feb 11, 2011·Human Mutation·Anja HeinemannCristina Has
Nov 28, 2015·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Jenny BreitenbachJohann W Bauer
May 28, 2019·Frontiers in Cell and Developmental Biology·Oindrila BhattacharjeeSrikala Raghavan
Oct 20, 2009·Journal of Cell Communication and Signaling·Kim S Midwood, Gertraud Orend
Dec 9, 2014·Cell Adhesion & Migration·Sean P Giblin, Kim S Midwood
Jun 27, 2002·Forensic Science International : Synergy·J A Ortiz-ReyL Concheiro-Carro

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