Dermokine as a novel biomarker for early-stage colorectal cancer.

Journal of Gastroenterology
Tomoyuki TagiEigo Otsuji

Abstract

Colorectal cancer is a common disease that is usually detected at an advanced stage, because early-stage cancer is mostly asymptomatic and appropriate serologic biomarkers have not been established. We have previously identified dermokine (DK) as a peptide secreted by keratinocytes and we found that DK-β/γ was expressed in colorectal tumors. Therefore, we focused on DK-β/γ as a new candidate diagnostic serum marker for early colorectal cancer. DK-β/γ expression in human colorectal cancer cell lines and tissues was assessed by quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR) and immunohistochemistry. We established an experimental enzyme-linked immunosorbent assay (ELISA) to detect DK-β/γ in the serum of colorectal cancer patients, and we compared the sensitivities of common diagnostic markers, carcinoembryonic antigen (CEA), carbohydrate antigen (CA) 19-9, and serum p53 antibody (S-p53). Immunohistochemical staining of colon tumor tissue with anti-DK monoclonal antibody (mAb) revealed that DK-β/γ was more commonly expressed in the early stages of colorectal cancer (Tis-T1; i.e., cancer in situ, intraepithelial or invasion of lamina propria [Tis]; tumor invades the submucosa [T1]) than in late-sta...Continue Reading

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Citations

Sep 20, 2011·Analytical and Bioanalytical Chemistry·Wei WeiSongqin Liu
Dec 13, 2012·Molecular & Cellular Proteomics : MCP·Stefan TholenOliver Schilling
Jul 14, 2012·PloS One·Shin NishiumiMasaru Yoshida
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Sep 20, 2019·Scandinavian Journal of Immunology·Shuxia LiuXiaohong Han
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Aug 10, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Adam R MorrisReuven Agami

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