Dermoscopic 'Chaos and Clues' in the diagnosis of melanoma in situ

The Australasian Journal of Dermatology
Rajan RamjiMarius Rademaker

Abstract

To describe the dermoscopic features of melanoma in situ using the Chaos and Clues method. Histologically proven primary melanoma in situ (MIS) diagnosed through a specialist teledermoscopy clinic were reviewed by three dermatologists. By consensus they agreed on the global dermoscopic pattern, colours, presence of chaos (asymmetry of colour and structure and more than one pattern), and each of the nine clues described for malignancy. One hundred MIS in 92 patients of European ethnicity (45 males) were assessed. Mean age was 67.3 years (range 20-95). The mean dimensions of the lesions were 11.1 × 12.0 mm (range 2.5-31.3 × 2.3-32.3 mm). Using pattern analysis, 82% of the lesions had three or more patterns (multicomponent) and the rest had 2 patterns. Colours included light brown (100%), dark brown (98%) and grey (75%). All MIS demonstrated chaos. The most prevalent clues were thick lines (88%), eccentric structureless areas (88%), and grey or blue structures (75%). Dermoscopy can be very helpful in the early diagnosis of melanoma and MIS. The Chaos and Clues method is simple to use. Its unambiguous descriptors can be successfully used to describe MIS. The presence of chaos and clues to malignancy (including thick lines, eccentri...Continue Reading

References

Dec 26, 2001·Archives of Dermatology·S W MenziesW H McCarthy
Jan 22, 2002·The American Journal of Dermatopathology·D MassiM Santucci
Mar 21, 2002·The Lancet Oncology·H KittlerM Binder
May 8, 2003·Journal of the American Academy of Dermatology·Chere R LucasJames M Grichnik
May 8, 2003·Journal of the American Academy of Dermatology·Giuseppe ArgenzianoAlfred W Kopf
Feb 23, 2005·Archives of Dermatology·Hans SkvaraHarald Kittler
Mar 29, 2011·Journal of the American Academy of Dermatology·Cliff RosendahlHarald Kittler
Feb 9, 2012·The Australasian Journal of Dermatology·David LimMarius Rademaker

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Citations

Aug 5, 2020·Pediatric Dermatology·Anshika KaushikElizabeth V Seiverling
Sep 22, 2018·Current Treatment Options in Oncology·Philipp WeberHarald Kittler
Jun 29, 2021·Experimental and Therapeutic Medicine·Cristina-Raluca Jitian MihuleceaMaria Rotaru

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