PMID: 6981830May 1, 1982Paper

Derrick Edward Award Lecture. The pathogenic potential of mycoplasmas: Mycoplasma pulmonis as a model

Reviews of Infectious Diseases
G H Cassell

Abstract

For years the ubiquity of Mycoplasma pulmonis in rodents overshadowed its pathogenic potential. Its etiologic significance in murine chronic respiratory disease was established only by recognition of the delicate equilibrium between organism and host. Environmental factors and genetic predisposition of the host rather than microbial virulence are the critical determinants of disease. The prevalence of M. pulmonis is undoubtedly related to the recently demonstrated in utero transmission and the ability of the organism to colonize and produce disease in the genital tract. The etiologic significance of Ureaplasma urealyticum in human genitourinary disease, like its murine counterpart, has been surrounded by controversy. Recent studies indicate that only a subgroup of colonized individuals develop clinical manifestations of disease, ranging from infertility to fetal wastage. While the natural occurrence of both respiratory and genital mycoplasmoses seriously restricts the usefulness of rats and mice for other research purposes, they represent useful models fo the study of human disease. The recognized morphologic similarities and similar natural histories of chronic bronchitis, bronchiectasis, and emphysema in humans and of M. pulm...Continue Reading

Citations

Jan 1, 1992·Annals of the Rheumatic Diseases·R Merilahti-PaloP Toivanen
Aug 26, 1998·Emerging Infectious Diseases·G H Cassell
Jul 1, 1995·DNA and Cell Biology·W C LaiS P Pakes
Jun 29, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nicole A DobbsJerry W Simecka
Apr 1, 1990·Environmental Health Perspectives·J I Everitt, C B Richter
Jul 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chandra Shekhar BakshiTimothy J Sellati
Nov 1, 1987·Infection and Immunity·R F ParkerG H Cassell
Nov 1, 1987·Infection and Immunity·H L WatsonG H Cassell
Jun 1, 1993·Infection and Immunity·S K HollingsheadS M Michalek
Jun 1, 1989·Infection and Immunity·H L WatsonG H Cassell
Oct 1, 1986·Infection and Immunity·J K DavisG H Cassell
Mar 1, 1993·Journal of Clinical Microbiology·F J van KuppeveldJ T van der Logt
Dec 1, 1996·Infection and Immunity·S C CartnerJ R Lindsey
Aug 1, 1988·Infection and Immunity·M K DavidsonG H Cassell

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