Des-γ-carboxyprothrombin (DCP) and NX-DCP expressions and their relationship with clinicopathological features in hepatocellular carcinoma

PloS One
Akiko SumiHirohisa Yano

Abstract

Des-γ-carboxyprothrombin (DCP) has been used as a tumor marker for hepatocellular carcinoma (HCC). Recently the DCP/NX-DCP ratio, calculated by dividing DCP by NX-DCP, has been reported useful in detecting HCC. The purpose of this study is to clarify the significance of DCP and NX-DCP expression in HCC tissues. HCC and non-HCC tissue samples were obtained from 157 patients and were immunohistochemically examined for DCP and NX-DCP expression using anti-DCP antibody and anti-NX-DCP antibody. DCP and NX-DCP expression scores were calculated by multiplying staining intensity grade by percentage of stained area. Serum DCP and NX-DCP levels were determined in 89 patients. We evaluated the relationship between tumor expression, serum level, and pathomorphological findings. Intrahepatic metastasis (im) was significantly more frequent in cases with high DCP expression than in cases with low DCP expression. High NX-DCP expression was associated with significantly lower histological grade, and less frequent im or portal vein invasion (vp) than low NX-DCP expression. Serum DCP was correlated with DCP expression, but serum NX-DCP was not correlated with NX-DCP expression. DCP-positive (≥40 mAU/L), NX-DCP-positive (≥90 mAU/L), and DCP/NX-DC...Continue Reading

References

Dec 4, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M FujiokaM Kojiro
Sep 22, 2005·Journal of Gastroenterology and Hepatology·Soichiro UeharaMitiko Senshuu
Oct 20, 2005·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Masatoshi Kudo
Jan 25, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Hidenori ToyodaJunji Washizu
Nov 3, 2009·The Lancet Oncology·Donald PoonUNKNOWN Asian Oncology Summit
Sep 30, 2010·Liver International : Official Journal of the International Association for the Study of the Liver·Yoshinori InagakiNorihiro Kokudo
Jun 30, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Annette S H GouwMasamichi Kojiro
Jul 12, 2011·Journal of Gastroenterology·Hideto SuzukiAtsushi Sakamoto
Sep 9, 2011·Nature Medicine·E W Thompson, I Haviv
Nov 29, 2011·Journal of Digestive Diseases·Yoshinori InagakiNorihiro Kokudo
May 5, 2012·Journal of Gastroenterology and Hepatology·Minoru MatsubaraKazuhide Yamamoto
Jan 26, 2013·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Koji MiyaharaUNKNOWN Okayama Liver Cancer Group
Feb 26, 2013·Journal of Gastroenterology and Hepatology·Takahiro TanakaTetsuji Takayama
Apr 26, 2013·Journal of Gastroenterology and Hepatology·Naoya Sakamoto
Sep 28, 2014·Best Practice & Research. Clinical Gastroenterology·Nicole Rich, Amit G Singal

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Citations

Oct 10, 2020·World Journal of Hepatology·Gurjot SinghBaljinder S Salh
Feb 11, 2021·Biomedicines·Nurbubu T MoldogazievaAlexander A Terentiev
Nov 3, 2020·The Journal of International Medical Research·Ting SongYun Tian
Sep 29, 2021·Expert Review of Molecular Diagnostics·Nurbubu T MoldogazievaAlexander A Terentiev

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