Descemet's membrane development, structure, function and regeneration

Experimental Eye Research
Rodrigo Carlos de Oliveira, Steven E Wilson

Abstract

Basement membranes are layers of extracellular matrix which anchor the epithelium or endothelium to connective tissues in most organs. Descemet's membrane- which is the basement membrane for the corneal endothelium- is a dense, thick, relatively transparent and cell-free matrix that separates the posterior corneal stroma from the underlying endothelium. It was historically named Descemet's membrane after Jean Descemet, a French physician, but it is also known as the posterior limiting elastic lamina, lamina elastica posterior, and membrane of Demours. Normal Descemet's membrane ultrastructure in humans has been shown to consist of an interfacial matrix that attaches to the overlying corneal stroma, an anterior banded layer and a posterior non-banded layer-upon which corneal endothelial cells attach. These layers have been shown to have unique composition and morphology, and to contribute to corneal homeostasis and clarity, participate in the control of corneal hydration and to modulate TGF-β-induced posterior corneal fibrosis. Pathophysiological alterations of Descemet's membrane are noted in ocular diseases such as Fuchs' dystrophy, bullous keratopathy, keratoconus, primary congenital glaucoma (Haab's striae), as well as in sy...Continue Reading

References

Jan 1, 1979·International Review of Cytology·E D Hay
Feb 1, 1976·American Journal of Ophthalmology·D L StoneS J Ryan
Apr 1, 1990·The Journal of Cell Biology·J M FitchT F Linsenmayer
Apr 1, 1989·European Journal of Biochemistry·R Timpl
Jan 1, 1986·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·P D YurchencoH Furthmayr
Oct 31, 1983·Biochemical and Biophysical Research Communications·U Labermeier, M C Kenney
Aug 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·J R HassellG R Martin
Jan 1, 1981·International Review of Connective Tissue Research·J G Heathcote, M E Grant
May 1, 1982·Experimental Cell Research·D K MacCallumS R Ledbetter
Dec 1, 1982·Archives of Ophthalmology·D H JohnsonR J Campbell
Apr 1, 1994·Matrix Biology : Journal of the International Society for Matrix Biology·R V Iozzo
Jan 23, 1998·The International Journal of Biochemistry & Cell Biology·C A Shuttleworth
Nov 1, 2001·Annual Review of Cell and Developmental Biology·R L Chow, R A Lang
Jul 25, 1956·The Journal of Biophysical and Biochemical Cytology·M A JAKUS
Oct 12, 2004·Annual Review of Cell and Developmental Biology·Jeffrey H Miner, Peter D Yurchenco
Jun 28, 2005·Matrix Biology : Journal of the International Society for Matrix Biology·Monique AumailleyPeter D Yurchenco
Oct 27, 2007·Investigative Ophthalmology & Visual Science·Andrea KabosovaAlexander V Ljubimov
Dec 7, 2007·American Journal of Ophthalmology·Gerrit R J MellesJacqueline van der Wees
Jan 26, 2008·Microscopy Research and Technique·Matthew S P HoNeil Smyth
Jan 26, 2008·Microscopy Research and Technique·Jamshid KhoshnoodiBilly G Hudson
Mar 24, 2009·Journal of Cataract and Refractive Surgery·Chandra BalachandranGerrit R J Melles
Apr 4, 2009·Journal of Structural Biology·Julie A LastChristopher J Murphy
Apr 10, 2009·Current Pharmaceutical Design·Peter D Yurchenco, Bruce L Patton
May 26, 2009·Molecules and Cells·Renato V IozzoAlexander Nyström
Apr 13, 2010·Matrix Biology : Journal of the International Society for Matrix Biology·Mahroo K ParsiMark A Gibson
Aug 10, 2010·Current Topics in Developmental Biology·Jochen Graw
Aug 23, 2011·Experimental Eye Research·Jeong Goo LeeEunDuck P Kay
Oct 19, 2012·Cell Adhesion & Migration·Erhard Hohenester, Peter D Yurchenco
May 30, 2013·Ophthalmology·Harminder S DuaJames Lowe
Jul 31, 2013·Experimental Eye Research·Wanzhou HuShin-ichi Ohnuma
Dec 3, 2014·Ophthalmology·Ursula Schlötzer-SchrehardtFriedrich E Kruse
Aug 25, 2015·The FEBS Journal·Willi HalfterMarija Plodinec
Aug 28, 2015·Progress in Molecular Biology and Translational Science·Allen O EghrariJohn D Gottsch
Aug 28, 2015·Progress in Molecular Biology and Translational Science·Peter Y Lwigale

❮ Previous
Next ❯

Citations

Feb 18, 2021·Experimental Eye Research·Lauren J JeangEdgar M Espana
Feb 20, 2021·The FEBS Journal·Nikos K KaramanosMaurizio Onisto
Apr 2, 2021·Journal of Anatomy·Shaun P Collin, H Barry Collin
Apr 4, 2021·Survey of Ophthalmology·Mohansrinivas ChennakesavaluDimitri T Azar
May 20, 2021·Experimental Eye Research·Paulina EscandonDimitrios Karamichos
Jul 4, 2021·Experimental Eye Research·Meng-Chen Tsai, Julie T Daniels
Nov 5, 2020·Experimental Eye Research·Willi HalfterPaul Bernhard Henrich

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.