PMID: 2106112Jan 1, 1990Paper

Description and clinical importance of the lymphatics of the vocal fold

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
J A WernerB Tillmann

Abstract

Findings of the presence of lymphatics in the subepithelial connective tissue layer of the true vocal cord range from the statement that lymphatics are absent to the observation that a dense lymphatic network exists. This is undoubtedly a result of the different methods of examination. The entire extent of a lymphatic system can be shown by either an enzyme histochemical demonstration of the 5'-nucleotidase activity in the lymphatics, or electron microscopy, which is more elaborate. These two methods are used to describe a subepithelial lymphatic network of varying density in 80 human vocal folds, which--contrary a frequent assumption--is not interrupted in the area of the free margin of the true vocal cord. Under the squamous epithelium, the density of the lymphatic system, which is very high in the arytenoid region, decreases continuously toward the anterior portion of the true vocal cord. It is exactly in the region in which the lymphatic system is the sparsest that almost all cancers of the true vocal cord develop. This finding is highly significant, in view of the low incidence of lymphogenous metastasis formation in T1-glottic cancers.

References

Dec 1, 1987·Archivum Histologicum Japonicum = Nihon Soshikigaku Kiroku·J A WernerB Tillmann
Jul 1, 1983·The Annals of Otology, Rhinology & Laryngology. Supplement·L W WelshT A Rizzo
Dec 1, 1959·The Journal of Laryngology and Otology·O H SHAHEEN

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Citations

Jan 1, 1992·Cancer Investigation·D Myssiorek
Mar 17, 2004·Annals of Surgical Oncology·Jochen A WernerThomas Behr
Feb 16, 2006·Surgical and Radiologic Anatomy : SRA·Y-H LiuM Zhang
Mar 23, 2002·Ophthalmic Plastic and Reconstructive Surgery·Briggs E CookB'Ann T Gabelt
Mar 28, 2021·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Cornelius H L KürtenTimon Hussain
Mar 25, 2000·Auris, Nasus, Larynx·H RaitiolaJ Pukander

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