Description of a large pedigree with an adverse lipoprotein cholesterol phenotype: the Bogalusa Heart Study

Genetic Epidemiology
P A RosenbaumG S Berenson

Abstract

A large pedigree (N = 356) with a high prevalence of heart disease and associated adverse lipoprotein phenotype was studied. The adverse lipoprotein phenotype is characterized by both low levels of high-density-lipoprotein cholesterol (HDL-C) alone (16.3%) and in combination with other adverse lipoprotein levels (12.8%). In all, 44.2% of all pedigree members had at least one adverse lipoprotein level. Analysis of mating types showed that all lipids and lipoproteins possess familial clustering with 25-36% of offspring above median levels when both parents had levels below the median, while 67-83% had levels above the median when both parents had levels above the median. Using adjusted lipid and lipoprotein levels, a statistically significant linear trend was found between the degree of relationship to pedigree members with heart disease, and both the low-density-lipoprotein cholesterol/high-density-lipoprotein cholesterol (LDL-C/HDL-C) ratio (P less than .05), and the very-low-density-lipoprotein cholesterol (VLDL-C; P less than .01) level. A similar analysis using the prevalence of adverse lipoprotein levels as the dependent variable and degree of relationship to heart diseased pedigree numbers as the independent variable showe...Continue Reading

Associated Clinical Trials

May 26, 2000·Lydia A. Bazzano

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Citations

Dec 4, 2009·PloS One·Lei ZhangHong-Wen Deng
Jul 1, 1987·American Journal of Medical Genetics·A AsamoahG S Berenson
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Jan 17, 2014·Journal of Indian Prosthodontic Society·Nadira A Hatim, Omar Zeno Al-Tahho
Dec 1, 1986·Acta Orthopaedica Scandinavica·B Gunterberg

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