Description of a novel approach for intraperitoneal drug delivery and the related device.

Surgical Endoscopy
Wiebke SolaßMarc A Reymond

Abstract

Two significant limitations of intraperitoneal drug therapy are limited drug distribution and poor penetration into peritoneal nodules. A possible solution is the application of the so-called "therapeutic pneumoperitoneum," taking advantage of the gaseous nature and the pressure of capnoperitoneum during laparoscopy. Our objective was to develop a device able to apply such therapeutic pneumoperitoneum. The technology presented here is a spraying device and can be introduced through a trocar. It is driven by mechanical pressure and consists of an injector, a line, and a nozzle. An in vivo experimental study was performed in five pigs. A transvaginal cholecystectomy was performed. At the end of the procedure, a standard dose of methylene blue was sprayed/infused into the abdominal cavity for 30 min (4 test animals w/therapeutic pneumoperitoneum (12 mmHg CO(2)) and 1 control animal w/conventional lavage (2 l intra-abdominal volume with extracorporeal circulation)). At the end of the procedure, all animals were autopsied and the peritoneum was analyzed. Outcome criteria were: (1) drug distribution (as assessed by the stained peritoneal surface at autopsy), and (2) diffusion into the peritoneum (presence or not of macroscopic staini...Continue Reading

References

Jan 1, 1990·Cancer Chemotherapy and Pharmacology·G LosJ G McVie
Jan 1, 1985·Critical Reviews in Oncology/hematology·M Markman
Jan 1, 1995·Annals of Surgery·P H Sugarbaker
Apr 2, 1997·Journal of the National Cancer Institute·R L Dedrick, M F Flessner
May 7, 2003·The Lancet Oncology·Maurie Markman
Dec 24, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dominique EliasJulia Bonastre
Jul 8, 2010·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·L Maggiori, D Elias
Sep 16, 2010·Anesthesia and Analgesia·Delphine BettonPierre Diemunsch

❮ Previous
Next ❯

Citations

Feb 5, 2013·Annals of Surgical Oncology·Ana BlancoMarc A Reymond
Jun 15, 2013·Annals of Surgical Oncology·Wiebke SolassMarc A Reymond
Oct 30, 2015·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Giorgi NadiradzeMarc-André Reymond
Nov 11, 2015·Annals of Surgical Oncology·Veria KhosrawipourUrs Giger-Pabst
Sep 25, 2015·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Cedric DemtröderMarc-André Reymond
Jul 17, 2016·Advanced Drug Delivery Reviews·George R DakwarKatrien Remaut
Sep 4, 2016·Journal of Cancer Research and Clinical Oncology·Veria KhosrawipourKhashayar Fakhrian
May 26, 2017·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Lieselotte LemoineKurt Van der Speeten
May 26, 2017·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Susana Sánchez-GarcíaJesús Martín-Fernández
Feb 28, 2019·Journal of Surgical Oncology·James P De AndradeYuman Fong
Sep 25, 2014·Wiener medizinische Wochenschrift·Clemens B TempferMarc-André Reymond
Dec 7, 2018·International Journal of Molecular Sciences·Ewa Pilch, Witold Musiał
Feb 1, 2020·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Axel DavigoVahan Kepenekian
Sep 1, 2017·Pleura and Peritoneum·Wouter WillaertWim Ceelen
Jun 23, 2018·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·H Leebmann, P Piso
May 14, 2019·Minerva medica·Andrea Di GiorgioStefano Rotolo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.