Description of a Qa-2 like alloantigen (Qa-m2)

European Journal of Immunology
P M HogarthI F McKenzie

Abstract

Several new aspects of the chemistry, genetics and cellular distribution of the murine Qa-2 alloantigen were apparent in an analysis of this antigen using monoclonal antibodies recognizing a Qa-2-like antigen called Qa-m2. Immunoprecipitation and sodium dodecyl sulfate polyacrylamide gel electrophoresis analysis identified the Qa-m2 alloantigen as a two-chain structure composed of a 39 000 dalton heavy chain and a 12 000 light chain which is probably beta 2-microglobulin; the heavy chain was readily distinguished from that of H-2. In addition, the expression of Qa-m2 alloantigens on the cell surface was found to be controlled by the H-2D gen with H-2Db strains carrying approximately 8-10 times greater amounts of Qa-m2 than strains carrying the H-2Dd or H-2Dq alleles. Finally, the Qa-m2 antigen, found predominantly on peripheral T cells, was present on only 10% of thymus cells. However, subpopulations of B cells (approximately 25% of all B cells) and bone marrow cells (15-20%) were also reactive. The monoclonal anti-Qa-m2 antibodies differed in their reactions from that reported for the conventional anti-Qa-2 sera, which must, therefore, be complex. The monoclonal antibodies may be useful reagents for functional analysis of T an...Continue Reading

References

Jan 1, 1979·Advances in Immunology·I F McKenzie, T Potter
Jul 1, 1979·The Journal of Experimental Medicine·G J HämmerlingL Flaherty
Jan 1, 1978·Journal of Immunological Methods·C R Parish, I F McKenzie
Jan 1, 1980·Immunogenetics·G M MorganD W Bailey
Jan 1, 1981·Immunogenetics·L FlahertyK DiBiase
Dec 1, 1980·European Journal of Immunology·T A PotterI F McKenzie

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Citations

Jan 1, 1983·Immunogenetics·P M HogarthI F McKenzie
Jan 1, 1989·Immunogenetics·S M Widacki, R G Cook
Jul 1, 1993·Journal of Reproductive Immunology·C M WarnerY Xu
Feb 1, 1985·Journal of Neuroimmunology·G H WongJ W Schrader
May 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·M J SoloskiA Lattimore
Jan 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·P J Robinson
May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M J SoloskiI Stroynowski
Jan 1, 1993·Microbiology and Immunology·E ParkD H Sacks
Jan 1, 1983·Immunology Today·I F McKenzie, H Zola
Oct 1, 1984·Journal of Immunogenetics·R A HarrisI F McKenzie
Feb 1, 1987·Journal of Immunogenetics·V R SuttonI F McKenzie
Oct 1, 1986·Journal of Immunogenetics·N FernandezR Flavell
Feb 1, 1985·Molecular and Cellular Biology·W D Cook

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