Description of an as yet unclassified DNA virus from diseased Cyprinus carpio species

Journal of Virology
Marina HutoranMoshe Kotler

Abstract

Numerous deaths of koi and common carp (Cyprinus carpio) were observed on many farms throughout Israel, resulting in severe financial losses. The lethal viral disease observed is highly contagious and extremely virulent, but morbidity and mortality are restricted to koi and common carp populations. Diseased fish exhibit fatigue and gasping movements in shallow water. Infected fish had interstitial nephritis and gill necrosis as well as petechial hemorrhages in the liver and other symptoms that were not consistent with viral disease, suggesting a secondary infection. Here we report the isolation of carp nephritis and gill necrosis virus (CNGV), which is the etiologic agent of this disease. The virus propagates and induces severe cytopathic effects by 5 days postinfection in fresh koi or carp fin cell cultures (KFC and CFC, respectively), but not in epithelioma papillosum cyprini cells. The virus harvested from KFC cultures induced the same clinical signs, with a mortality of 75 to 95%, upon inoculation into naive koi and common carp. Using PCR, we provide final proof that the isolated virus is indeed the etiologic agent of food and ornamental carp mortalities in fish husbandry. Electron microscopy revealed viral cores with icosa...Continue Reading

References

Jan 1, 1975·Intervirology·E M DoughertyC F Reichelderfer
Oct 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·Y Stern-BachS Schuldiner
Jan 1, 1992·Virology·Andrew J Davison
Oct 1, 1990·Journal of Wildlife Diseases·Ronald P HedrickT S McDowell
Nov 1, 1990·Virology·S J GoebelE Paoletti
Jan 1, 1990·Advances in Experimental Medicine and Biology·B Roizman
Nov 25, 1989·Nucleic Acids Research·M A Alting-Mees, J M Short
Jul 1, 1988·The Journal of General Virology·Duncan J McGeochP Taylor
Sep 1, 1997·Nucleic Acids Research·S F AltschulD J Lipman
Apr 18, 2000·Diseases of Aquatic Organisms·Teruo MiyazakiT Kobayashi
Mar 1, 2000·Journal of Aquatic Animal Health·Ronald P HedrickAvi Eldar

Citations

May 15, 2007·Archives of Virology·Maya DavidovichMoshe Kotler
Jul 31, 2013·In Vitro Cellular & Developmental Biology. Animal·Jingxiang ZhouDongming Zhang
Sep 3, 2013·Indian Journal of Virology : an Official Organ of Indian Virological Society·Gaurav RathoreP Swain
Nov 5, 2005·Applied and Environmental Microbiology·Arnon DishonMoshe Kotler
Feb 16, 2007·Journal of Virology·Arnon DishonMoshe Kotler
Jan 21, 2009·Journal of Virology·Bérénice CostesAlain Vanderplasschen
Mar 10, 2006·Microbiology and Molecular Biology Reviews : MMBR·Maya IlouzeMoshe Kotler
Nov 26, 2005·Uirusu·Takaji Iida, M Sano
Dec 3, 2010·Emerging Infectious Diseases·Benjamin MichelAlain Vanderplasschen
Jul 23, 2013·Diseases of Aquatic Organisms·M GotesmanMansour El-Matbouli
Dec 14, 2011·Viruses·Larry HansonMoshe Kotler
Nov 14, 2014·Diseases of Aquatic Organisms·Mi-Young ChoSuhee Hong
Jun 11, 2015·Veterinary Microbiology·Graham BrogdenDieter Steinhagen
May 7, 2013·The Veterinary Clinics of North America. Exotic Animal Practice·Colin McDermott, Brian Palmeiro
Nov 14, 2012·Veterinary Microbiology·Chuanfu DongJianguo He
Dec 15, 2010·Journal of Theoretical Biology·Ryosuke Omori, Ben Adams
Aug 21, 2010·Research in Veterinary Science·Mansour El-Matbouli, Hatem Soliman
Oct 13, 2009·Journal of Virological Methods·S M BergmannJ Kempter
May 12, 2009·Journal of Virological Methods·L BigarréJ Castric
Nov 24, 2007·Journal of Fish Diseases·S MiwaM Sano
Feb 24, 2006·Virus Research·Duncan J McGeochAndrew J Davison
Mar 18, 2008·The Journal of General Virology·Daniela RosenkranzWalter Fuchs
Nov 24, 2012·Journal of Virological Methods·Jia-Rong XuLing Jin
Mar 7, 2017·Diseases of Aquatic Organisms·Sharon C ClouthierEric D Anderson
Sep 19, 2014·Journal of Clinical Microbiology·Marina EyngorAvi Eldar
May 26, 2005·The Journal of General Virology·Thomas B WaltzekRonald P Hedrick
Jan 8, 2021·Fish Physiology and Biochemistry·Ying LiYugu Li

Related Concepts

AY208988
AY208989
AY208990
AY208991
AY661550
Metazoa
Cyprinus
DNA Viruses
DNA, Viral
Fish Diseases

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