Description of CD8+ Regulatory T Lymphocytes and Their Specific Intervention in Graft-versus-Host and Infectious Diseases, Autoimmunity, and Cancer

Journal of Immunology Research
Martha R Vieyra-LobatoMartha C Moreno-Lafont

Abstract

Gershon and Kondo described CD8+ Treg lymphocytes as the first ones with regulating activity due to their tolerance ability to foreign antigens and their capacity to inhibit the proliferation of other lymphocytes. Regardless, CD8+ Treg lymphocytes have not been fully described-unlike CD4+ Treg lymphocytes-because of their low numbers in blood and the lack of specific and accurate population markers. Still, these lymphocytes have been studied for the past 30 years, even after finding difficulties during investigations. As a result, studies have identified markers that define their subpopulations. This review is focused on the expression of cell membrane markers as CD25, CD122, CD103, CTLA-4, CD39, CD73, LAG-3, and FasL as well as soluble molecules such as FoxP3, IFN-γ, IL-10, TGF-β, IL-34, and IL-35, in addition to the lack of expression of cell activation markers such as CD28, CD127 CD45RC, and CD49d. This work also underlines the importance of identifying some of these markers in infections with several pathogens, autoimmunity, cancer, and graft-versus-host disease as a strategy in their prevention, monitoring, and cure.

References

Jan 1, 1996·European Journal of Immunology·S KanangatM Deheshia
Jun 1, 1996·The Journal of Experimental Medicine·T L WalunasJ A Bluestone
Dec 22, 1999·The Journal of Immunology : Official Journal of the American Association of Immunologists·T CinekJ B Imboden
Jul 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·B M CarrenoJ Madrenas
Aug 3, 2001·The Journal of Biological Chemistry·L A SchubertS F Ziegler
Jun 5, 2002·The Journal of Experimental Medicine·Philippe PoussierMichael Julius
Aug 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Naeem KhanPaul A H Moss
Sep 5, 2002·European Journal of Immunology·Creg J WorkmanDario A A Vignali
Oct 9, 2002·The Journal of Experimental Medicine·Adam D JudgeJonathan Sprent
Oct 24, 2002·Human Immunology·Urban J ScheuringArgyrios N Theofilopoulos
Nov 5, 2002·Annual Review of Immunology·Michelle L HermistonArthur Weiss
Oct 3, 2003·The Journal of Clinical Investigation·Nader NajafianSamia J Khoury
Mar 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Katharina M HusterDirk H Busch
Nov 3, 2004·The Journal of Experimental Medicine·Muhaimin Rifa'iHaruhiko Suzuki
Feb 3, 2005·Nature Immunology·Hans Christian ProbstMaries van den Broek
May 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael J FullerAllan J Zajac
May 12, 2005·Immunology·Laëtitia Maçon-Lemaître, Frédéric Triebel
Nov 23, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Agustina Tri EndhartiHaruhiko Suzuki
Jul 5, 2006·The Journal of Experimental Medicine·Weihong LiuJeffrey A Bluestone
Jul 26, 2006·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Katharine C HsuUNKNOWN International Histocompatibility Working Group
Aug 22, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jared E LopesSteven F Ziegler
Dec 23, 2006·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Vinodh PillaiNitin J Karandikar
Mar 3, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·I PopescuD Metes
Apr 4, 2007·The Journal of Clinical Investigation·Carole GuillonneauIgnacio Anegon
Apr 19, 2007·Multiple Sclerosis : Clinical and Laboratory Research·Guang-Zhi LiuXu-Guang Gao
May 16, 2007·The Journal of Experimental Medicine·Silvia DeaglioSimon C Robson
Sep 20, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gilberto FilaciFrancesco Indiveri
Oct 13, 2007·The Journal of Clinical Investigation·Joseph F GrossoCharles G Drake

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Citations

Nov 13, 2018·Biomaterials Science·Elana Ben-AkivaJordan J Green
Oct 9, 2019·Immunological Reviews·Léa FlippeCarole Guillonneau
Jan 8, 2020·Journal of Clinical Laboratory Analysis·Mariel García-ChagollánJosé Francisco Muñoz-Valle
Aug 25, 2020·Annals of Clinical and Translational Neurology·Priscilla Bäcker-KoduahAlexander Ulrich Brandt
Apr 17, 2020·Frontiers in Cellular and Infection Microbiology·Lili DingPujun Gao
Jun 12, 2019·International Journal of Molecular Sciences·Wei X HuffMahua Dey
Dec 16, 2020·Scientific Reports·Genevieve N MullinsKatrina K Hoyer
Jan 28, 2021·European Journal of Immunology·Veronika NiederlovaOndrej Stepanek
Feb 23, 2021·Frontiers in Pharmacology·Anna Lisa GiulianiFrancesco Di Virgilio
Mar 27, 2021·Frontiers in Immunology·Giulia PiaggeschiAlessia Visconti
May 12, 2021·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Hao LiYing-Zi Ming
Aug 8, 2021·International Journal of Molecular Sciences·Eleonora Timperi, Vincenzo Barnaba
Aug 17, 2021·Frontiers in Immunology·Daniil ShevyrevVladimir Kozlov

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pharmacotherapy

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