Descriptions of Adverse Drug Reactions Are Less Informative in Forums Than in the French Pharmacovigilance Database but Provide More Unexpected Reactions

Frontiers in Pharmacology
Pierre KarapetiantzCédric Bousquet

Abstract

Background: Social media have drawn attention for their potential use in Pharmacovigilance. Recent work showed that it is possible to extract information concerning adverse drug reactions (ADRs) from posts in social media. The main objective of the Vigi4MED project was to evaluate the relevance and quality of the information shared by patients on web forums about drug safety and its potential utility for pharmacovigilance. Methods: After selecting websites of interest, we manually evaluated the relevance of the content of posts for pharmacovigilance related to six drugs (agomelatine, baclofen, duloxetine, exenatide, strontium ranelate, and tetrazepam). We compared forums to the French Pharmacovigilance Database (FPVD) to (1) evaluate whether they contained relevant information to characterize a pharmacovigilance case report (patient's age and sex; treatment indication, dose and duration; time-to-onset (TTO) and outcome of the ADR, and drug dechallenge and rechallenge) and (2) perform impact analysis (nature, seriousness, unexpectedness, and outcome of the ADR). Results: The cases in the FPVD were significantly more informative than posts in forums for patient description (age, sex), treatment description (dose, duration, TTO), ...Continue Reading

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Citations

Oct 21, 2018·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Cedric BousquetAgnès Lillo-Le Louët
Nov 9, 2019·Journal of Medical Internet Research·Jill S BorchertKirk E Dineley
Jun 20, 2020·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Bissan AudehCédric Bousquet
Jun 20, 2020·Thérapie·Malak Abou TaamUNKNOWN Réseau français des centres régionaux de pharmacovigilance
Jun 30, 2019·Thérapie·Pierre KarapetiantzCédric Bousquet

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Software Mentioned

MeaMedica
ANSM
Vigi4MED
Vigi4Med Scraper

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