Descriptive analytical data and consequences for calculation of common reference intervals in the Nordic Reference Interval Project 2000

Scandinavian Journal of Clinical and Laboratory Investigation
P RustadP Hyltoft Petersen

Abstract

In the Nordic Reference Interval Project (NORIP), data from 102 Nordic clinical chemical laboratories were obtained. Each laboratory reported analytical data on up to 25 of the most commonly used clinical biochemical properties, including results from each of a minimum of 25 reference individuals. A reference material consisting of a liquid frozen pool of serum with values traceable to reference methods (used as the project "calibrator" for non-enzymes to correct reference values) was measured together with other serum pool controls in each laboratory in the same analytical series as the project samples. The data on the controls were used to evaluate the analytical quality of the routine methods. For reference interval calculations, only such reference values on enzymes were accepted that were obtained by applying the International Federation of Clinical Chemistry (IFCC) compatible methods (37 degrees C), while "calibrator"-corrected reference values were used in the cases of non-enzymes. For each property, gender- and age-specific reference intervals were estimated, based on simple non-parametric calculations and using objective criteria to perform partitioning into subgroups. It is concluded that the same reference intervals ...Continue Reading

References

Jun 30, 2004·Scandinavian Journal of Clinical and Laboratory Investigation·P RustadA Uldall
Jun 30, 2004·Scandinavian Journal of Clinical and Laboratory Investigation·P Rustad, P Hyltoft Petersen

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