Descriptive Epidemiology and Whole Genome Sequencing Analysis for an Outbreak of Bovine Tuberculosis in Beef Cattle and White-Tailed Deer in Northwestern Minnesota

PloS One
Linda GlaserBruce Thomsen

Abstract

Bovine tuberculosis (bTB) was discovered in a Minnesota cow through routine slaughter surveillance in 2005 and the resulting epidemiological investigation led to the discovery of infection in both cattle and white-tailed deer in the state. From 2005 through 2009, a total of 12 beef cattle herds and 27 free-ranging white-tailed deer (Odocoileus virginianus) were found infected in a small geographic region of northwestern Minnesota. Genotyping of isolates determined both cattle and deer shared the same strain of bTB, and it was similar to types found in cattle in the southwestern United States and Mexico. Whole genomic sequencing confirmed the introduction of this infection into Minnesota was recent, with little genetic divergence. Aggressive surveillance and management efforts in both cattle and deer continued from 2010-2012; no additional infections were discovered. Over 10,000 deer were tested and 705 whole herd cattle tests performed in the investigation of this outbreak.

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Citations

Feb 22, 2017·Emerging Infectious Diseases·Jennifer A DavidsonDominik Zenner
May 26, 2017·American Journal of Veterinary Research·Sylvia I WanzalaSrinand Sreevatsan
Apr 18, 2018·PLoS Neglected Tropical Diseases·Michael Kahsay GhebremariamAnita L Michel
Aug 24, 2018·PloS One·Claudia Angélica Perea RazoGerminal Jorge Cantó Alarcón
Sep 12, 2018·Tropical Animal Health and Production·Leila JahangiryParvin Sarbakhsh
Nov 15, 2018·Frontiers in Veterinary Science·Kathy OrloskiMark Schoenbaum
Feb 17, 2021·PLoS Neglected Tropical Diseases·Carlos Arturo Vázquez-ChacónPaúl Alexis López-Durán
Oct 14, 2018·Preventive Veterinary Medicine·Szu-Yu Zoe KaoScott J Wells

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Methods Mentioned

BETA
Necropsies
PCR
genotyping

Software Mentioned

UnifiedGenotyper
RAxML
BEAST
Tracer
Samtools
NVSL
GATK
BWA
Integrative Genomics Viewer ( IGV )
Genome Analysis Toolkit ( GATK )

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