Descriptive epidemiology of cerebellar hypoplasia in the National Birth Defects Prevention Study

Birth Defects Research
Meredith M HowleyNational Birth Defects Prevention Study

Abstract

Cerebellar hypoplasia is a rare disorder of cerebellar formation in which the cerebellum is not completely developed, smaller than it should be, or completely absent. The prevalence of cerebellar hypoplasia at birth is unknown, and little is known about epidemiological risk factors. Using data from the National Birth Defects Prevention Study (NBDPS), a population-based, case-control study, we analyzed clinical features and potential risk factors for nonsyndromic cerebellar hypoplasia. The NBDPS included pregnancies with estimated delivery dates from 1997-2011. We described clinical features of cerebellar hypoplasia cases from the study area. We explored risk factors for cerebellar hypoplasia (case characteristics, demographics, pregnancy characteristics, maternal health conditions, maternal medication use, and maternal behavioral exposures) by comparing cases to non-malformed live born control infants. We calculated crude odds ratios (ORs) and 95% confidence intervals using logistic regression models. We identified 87 eligible cerebellar hypoplasia cases and 55 mothers who participated in the NBDPS. There were no differences in clinical features between interviewed and non-interviewed cases. Cerebellar hypoplasia cases were mor...Continue Reading

References

Dec 1, 1979·The Journal of Pediatrics·A A SchinzelJ R Miller
Aug 1, 1990·Developmental Medicine and Child Neurology·W SquierR H Lindenbaum
Jan 1, 1980·Developmental Neuroscience·M C Bohn, J M Lauder
Oct 1, 1996·Pediatric Neurology·M I Shevell, A Majnemer
Oct 1, 1996·Pediatric Neurology·M I SteinlinE J Boltshauser
Aug 5, 1998·Neuroradiology·M SteinlinE Boltshauser
Sep 15, 1998·Trends in Neurosciences·D Goldowitz, K Hamre
Aug 27, 1999·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·H PinarD B Singer
Apr 15, 2000·Journal of Perinatal Medicine·Y JacquemynP Verdonk
Aug 6, 2000·Archives of Internal Medicine·C BelliniG Serra
Oct 31, 2000·Neuron·C I Rodriguez, S M Dymecki
Apr 6, 2002·Reproductive Toxicology·S MatalonA Ornoy
Jul 25, 2003·Pediatric Neurology·Evangeline WassmerStuart H Green
Oct 22, 2003·Molecular Genetics and Metabolism·Melissa A Parisi, William B Dobyns
Mar 3, 2005·Pediatrics·Catherine LimperopoulosAdré J du Plessis
Jul 19, 2006·Archives of Gynecology and Obstetrics·Edward Araujo JúniorRosiane Mattar
Sep 27, 2006·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·F K Afadapa, K Elsapagh
Nov 15, 2006·Circulation·Mary S Minette, David J Sahn
Sep 18, 2007·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Andrea PorettiEugen Boltshauser
Oct 24, 2008·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Andrea PorettiEugen Boltshauser
Sep 5, 2009·Developmental Disabilities Research Reviews·Andria L NormanEdward P Riley
Oct 13, 2009·The Journal of Pediatrics·Mikael EkbladUNKNOWN PIPARI Study Group
Jan 12, 2010·Human Reproduction Update·Marleen M H J van GelderNel Roeleveld
Dec 4, 2010·BMJ : British Medical Journal·Janneke JentinkUNKNOWN EUROCAT Antiepileptic Study Working Group
Oct 21, 2011·Science Translational Medicine·Emily W Y TamSteven P Miller
Nov 14, 2012·Cerebral Cortex·Catherine LimperopoulosAdré J du Plessis
Jul 12, 2013·Neuroradiology·Emily W Y Tam
Oct 11, 2013·Human Reproduction·Marleen M H J van GelderNel Roeleveld
May 20, 2014·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Andrea PorettiDan Doherty
Jan 15, 2015·American Journal of Reproductive Immunology : AJRI·Michelle SilasiGil Mor
May 6, 2015·American Journal of Medical Genetics. Part a·Matthew R ReederUNKNOWN National Birth Defects Prevention Study
Jun 3, 2015·Birth Defects Research. Part A, Clinical and Molecular Teratology·Jennita ReefhuisUNKNOWN National Birth Defects Prevention Study
Jan 29, 2016·MMWR. Morbidity and Mortality Weekly Report·Lavinia Schuler-FacciniUNKNOWN Brazilian Medical Genetics Society–Zika Embryopathy Task Force
Apr 7, 2016·The New England Journal of Medicine·Adriano N HazinUNKNOWN Microcephaly Epidemic Research Group
Jun 22, 2016·Journal of Epidemiology and Community Health·April L DawsonUNKNOWN National Birth Defects Prevention Study
Aug 3, 2016·Seminars in Fetal & Neonatal Medicine·Catherine Limperopoulos
Oct 4, 2016·JAMA Neurology·Adriana Suely de Oliveira MeloAmilcar Tanuri
Nov 16, 2016·The Journal of Pediatrics·Marie Brossard-RacineCatherine Limperopoulos
Dec 17, 2016·Clinica Chimica Acta; International Journal of Clinical Chemistry·Chen JiangLingqian Wu
Dec 17, 2016·Neuroscience·Stacey L Main, Randy J Kulesza
Jan 31, 2017·Current Opinion in Obstetrics & Gynecology·Edward Araujo JúniorHeron Werner
Feb 17, 2017·Scientific Reports·Chandramohan SubashiniJackson James

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Related Papers

Birth Defects Research. Part A, Clinical and Molecular Teratology
Meredith M HowleyNational Birth Defects Prevention Study
Birth Defects Research
Meredith M HowleyNational Birth Defects Prevention Study
© 2022 Meta ULC. All rights reserved